BTNL8, a butyrophilin-like molecule that costimulates the primary immune response

Andrei I. Chapoval, Glennda Smithson, Linda Brunick, Mehdi Mesri, Ferenc L. Boldog, David Andrew, Nikolai V. Khramtsov, Elena A. Feshchenko, Gary C. Starling, Peter S. Mezes

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

The role of the B7 family molecules in the regulation of the immune response is well documented. A large body of experimental evidence indicates that costimulatory molecules such as B7-1, B7-2, B7-DC, B7-H1, B7-H2, B7-H3 and B7-H4 are critical for initiation, maintenance and down-regulation of the immune response. However the immunological function of butyrophilin (BTN)-like molecules, which are a part of the expanded B7 family, is not known. Here, we demonstrate that the extracellular portion of human BTNL8 can augment Ag-induced activation of T lymphocytes. BTNL8 has two alternatively spliced forms: B7-like and BTN-like. Both isoforms of BTNL8 were expressed concurrently in various human tissues. A putative BTNL8 receptor was detected only on resting T lymphocytes. Administration of BTNL8Ig fusion protein into mice promoted production of Ag-specific IgG during the primary, but not the secondary immune responses. BTNL8 may therefore play an essential role in priming of naïve T lymphocytes.

Original languageEnglish (US)
Pages (from-to)819-828
Number of pages10
JournalMolecular Immunology
Volume56
Issue number4
DOIs
StatePublished - Dec 31 2013
Externally publishedYes

Keywords

  • Cell activation
  • Costimulation
  • Cytokines
  • T cells

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology

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