@article{06305701ac014fed83954f964cbda7a8,
title = "Bryostatin 1 antagonizes the terminal differentiating action of 12-O-tetradecanoylphorbol-13-acetate in a human colon cancer cell",
abstract = "12-O-Tetradecanoylphorbol-13-acetate (TPA), a highly active representative of the tumor-promoting phorbol esters, induces a rapid terminal differentiation of a human colon cancer cell line. Bryostatln 1, a macrocyclic lactone, completely counter-acts this effect of TPA and promotes continued replication. The observed responses provide a system for identifying cellular processes which are involved in the induced terminal differentiation of human colon cancer cells.",
author = "Mcbain, {John A.} and George Pettit and Mueller, {Gerald C.}",
note = "Funding Information: The authors thank Mr Jerry Saltier for the photomicrographs and Ms Mary LcMahieu for assistance in the preparation of the manuscript and Drs Cherry L.HeraW, John Leet and Yoshiald Kamano. This work is supported by NCI Grants CA-23076, CA-07175 and CA-16049-08-11 and NIH Training Grant CA-O9O3O. Gerald C.Mueller is the recipient of Research Career Award, CA-00685 from the NCI.",
year = "1988",
month = jan,
doi = "10.1093/carcin/9.1.123",
language = "English (US)",
volume = "9",
pages = "123--129",
journal = "Carcinogenesis",
issn = "0143-3334",
publisher = "Oxford University Press",
number = "1",
}