Bryostatin 1 antagonizes the terminal differentiating action of 12-O-tetradecanoylphorbol-13-acetate in a human colon cancer cell

John A. Mcbain, George Pettit, Gerald C. Mueller

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

12-O-Tetradecanoylphorbol-13-acetate (TPA), a highly active representative of the tumor-promoting phorbol esters, induces a rapid terminal differentiation of a human colon cancer cell line. Bryostatln 1, a macrocyclic lactone, completely counter-acts this effect of TPA and promotes continued replication. The observed responses provide a system for identifying cellular processes which are involved in the induced terminal differentiation of human colon cancer cells.

Original languageEnglish (US)
Pages (from-to)123-129
Number of pages7
JournalCarcinogenesis
Volume9
Issue number1
DOIs
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Cancer Research

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