Bryostatin 1 antagonizes the terminal differentiating action of 12-O-tetradecanoylphorbol-13-acetate in a human colon cancer cell

John A. Mcbain, George Pettit, Gerald C. Mueller

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

12-O-Tetradecanoylphorbol-13-acetate (TPA), a highly active representative of the tumor-promoting phorbol esters, induces a rapid terminal differentiation of a human colon cancer cell line. Bryostatln 1, a macrocyclic lactone, completely counter-acts this effect of TPA and promotes continued replication. The observed responses provide a system for identifying cellular processes which are involved in the induced terminal differentiation of human colon cancer cells.

Original languageEnglish (US)
Pages (from-to)123-129
Number of pages7
JournalCarcinogenesis
Volume9
Issue number1
DOIs
StatePublished - Jan 1988

Fingerprint

Tetradecanoylphorbol Acetate
Colonic Neoplasms
Cancer
Cells
Cell
Phorbol Esters
Lactones
Replication
Tumors
Tumor
Esters
Cell Line
Line
Neoplasms
bryostatin 1
Human
Cell line

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Physiology
  • Behavioral Neuroscience
  • Cancer Research

Cite this

Bryostatin 1 antagonizes the terminal differentiating action of 12-O-tetradecanoylphorbol-13-acetate in a human colon cancer cell. / Mcbain, John A.; Pettit, George; Mueller, Gerald C.

In: Carcinogenesis, Vol. 9, No. 1, 01.1988, p. 123-129.

Research output: Contribution to journalArticle

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