Bridging one helical turn in double-stranded DNA by templated dimerization of molecular rods

Casper S. Andersen; Hao Yan; Kurt V. Gothelf

doi:10.1002/anie.200800819

Bridging one helical turn in double-stranded DNA by templated dimerization of molecular rods

Casper S. Andersen, Hao Yan, Kurt V. Gothelf

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

(Figure Presented) A molecular bridge: A molecular rod composed of a substituted oligo(phenylene ethynylene) backbone with salicylaldehyde moieties in the terminal positions was conjugated to short 10-base-pair DNA sequences (shown in red). The assembly of two such conjugates on a DNA template (blue) aligns the two molecules for reaction in the presence of ethylenediamine and a metal salt to form a metal-salen complex.

Original language	English (US)
Pages (from-to)	5569-5572
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	47
Issue number	30
DOIs	https://doi.org/10.1002/anie.200800819
State	Published - Jul 14 2008

Keywords

DNA
Metal-salen complexes
Molecular electronics
Nanostructures
Self-assembly

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.200800819

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AU - Yan, Hao

AU - Gothelf, Kurt V.

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Y1 - 2008/7/14

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AB - (Figure Presented) A molecular bridge: A molecular rod composed of a substituted oligo(phenylene ethynylene) backbone with salicylaldehyde moieties in the terminal positions was conjugated to short 10-base-pair DNA sequences (shown in red). The assembly of two such conjugates on a DNA template (blue) aligns the two molecules for reaction in the presence of ethylenediamine and a metal salt to form a metal-salen complex.

KW - DNA

KW - Metal-salen complexes

KW - Molecular electronics

KW - Nanostructures

KW - Self-assembly

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Bridging one helical turn in double-stranded DNA by templated dimerization of molecular rods

Abstract

Keywords

ASJC Scopus subject areas

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