Brain surface conformal parameterization with the ricci flow

Yalin Wang, Jie Shi, Xiaotian Yin, Xianfeng Gu, Tony F. Chan, Shing Tung Yau, Arthur W. Toga, Paul M. Thompson

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

In brain mapping research, parameterized 3-D surface models are of great interest for statistical comparisons of anatomy, surface-based registration, and signal processing. Here, we introduce the theories of continuous and discrete surface Ricci flow, which can create Riemannian metrics on surfaces with arbitrary topologies with user-defined Gaussian curvatures. The resulting conformal parameterizations have no singularities and they are intrinsic and stable. First, we convert a cortical surface model into a multiple boundary surface by cutting along selected anatomical landmark curves. Secondly, we conformally parameterize each cortical surface to a parameter domain with a user-designed Gaussian curvature arrangement. In the parameter domain, a shape index based on conformal invariants is computed, and inter-subject cortical surface matching is performed by solving a constrained harmonic map. We illustrate various target curvature arrangements and demonstrate the stability of the method using longitudinal data. To map statistical differences in cortical morphometry, we studied brain asymmetry in 14 healthy control subjects. We used a manifold version of Hotelling's T 2 test, applied to the Jacobian matrices of the surface parameterizations. A permutation test, along with the cumulative distribution of p-values, were used to estimate the overall statistical significance of differences. The results show our algorithm's power to detect subtle group differences in cortical surfaces.

Original languageEnglish (US)
Article number6020804
Pages (from-to)251-264
Number of pages14
JournalIEEE Transactions on Medical Imaging
Volume31
Issue number2
DOIs
StatePublished - Feb 1 2012

Keywords

  • Brain surface parameterization
  • Ricci flow
  • conformal mapping
  • multivariate tensor-based morphometry

ASJC Scopus subject areas

  • Software
  • Radiological and Ultrasound Technology
  • Computer Science Applications
  • Electrical and Electronic Engineering

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  • Cite this

    Wang, Y., Shi, J., Yin, X., Gu, X., Chan, T. F., Yau, S. T., Toga, A. W., & Thompson, P. M. (2012). Brain surface conformal parameterization with the ricci flow. IEEE Transactions on Medical Imaging, 31(2), 251-264. [6020804]. https://doi.org/10.1109/TMI.2011.2168233