Blood lactate during exercise: Time course of training adaptation in humans

Glenn Gaesser, D. C. Poole

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

We determined the time course of adaptation in blood lactate concentration ([La]) during constant-load exercise in response to training. Thirteen healthy subjects (11 males, 2 females) exercised on a cycle ergometer for 30 min/day at a work rate calculated to elicit 70% of pre-training V̇O2max, 6 days/week for 3 weeks. V̇O2max and blood [La] during constant-load exercise (training work rate) were determined at the end of each week of training. Training increased V̇O2max 8.5% (from 48.2 ± 1.5 ml·kg-1·min-1 pre-training to 52.3 ± 1.4 ml·kg-1·min-1 post-training, P < 0.01) and decreased constant-load blood [La] 53% (from 7.8 ± 0.6 mM pre-training to 3.7 ± 0.3 mM post-training, P < 0.01). The training-induced reduction in exercise blood [La] was well fit to an exponential (5.5 e((-t/2.2)) + 2.3, r = 0.99) with a half-time of 10.7 days. However, this was not the case for the time course of V̇O2max adaptation. The absolute decrease in blood [La] was correlated with the initial blood [La] (r = 0.88, P < 0.01), but changes in V̇O2max were not significantly correlated with initial blood [La] (r = -0.14) nor with changes in blood [La] (r = -0.02). We conclude that (1) blood [La] response to constant-load exercise decreases rapidly and exponentially with training, with a t( 1/2 ) of 10.7 days, (2) the magnitude of training adaptation is positively related to the initial blood [La], and (3) the time course and extent of the training-induced adaptations of blood [La] and V̇O2max appear to be independent of one another.

Original languageEnglish (US)
Pages (from-to)284-288
Number of pages5
JournalInternational Journal of Sports Medicine
Volume9
Issue number4
StatePublished - 1988
Externally publishedYes

Fingerprint

Lactic Acid
Exercise
Healthy Volunteers

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Public Health, Environmental and Occupational Health
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Blood lactate during exercise : Time course of training adaptation in humans. / Gaesser, Glenn; Poole, D. C.

In: International Journal of Sports Medicine, Vol. 9, No. 4, 1988, p. 284-288.

Research output: Contribution to journalArticle

@article{b5219febef37418b97eedc477659aa6b,
title = "Blood lactate during exercise: Time course of training adaptation in humans",
abstract = "We determined the time course of adaptation in blood lactate concentration ([La]) during constant-load exercise in response to training. Thirteen healthy subjects (11 males, 2 females) exercised on a cycle ergometer for 30 min/day at a work rate calculated to elicit 70{\%} of pre-training V̇O2max, 6 days/week for 3 weeks. V̇O2max and blood [La] during constant-load exercise (training work rate) were determined at the end of each week of training. Training increased V̇O2max 8.5{\%} (from 48.2 ± 1.5 ml·kg-1·min-1 pre-training to 52.3 ± 1.4 ml·kg-1·min-1 post-training, P < 0.01) and decreased constant-load blood [La] 53{\%} (from 7.8 ± 0.6 mM pre-training to 3.7 ± 0.3 mM post-training, P < 0.01). The training-induced reduction in exercise blood [La] was well fit to an exponential (5.5 e((-t/2.2)) + 2.3, r = 0.99) with a half-time of 10.7 days. However, this was not the case for the time course of V̇O2max adaptation. The absolute decrease in blood [La] was correlated with the initial blood [La] (r = 0.88, P < 0.01), but changes in V̇O2max were not significantly correlated with initial blood [La] (r = -0.14) nor with changes in blood [La] (r = -0.02). We conclude that (1) blood [La] response to constant-load exercise decreases rapidly and exponentially with training, with a t( 1/2 ) of 10.7 days, (2) the magnitude of training adaptation is positively related to the initial blood [La], and (3) the time course and extent of the training-induced adaptations of blood [La] and V̇O2max appear to be independent of one another.",
author = "Glenn Gaesser and Poole, {D. C.}",
year = "1988",
language = "English (US)",
volume = "9",
pages = "284--288",
journal = "International Journal of Sports Medicine",
issn = "0172-4622",
publisher = "Georg Thieme Verlag",
number = "4",

}

TY - JOUR

T1 - Blood lactate during exercise

T2 - Time course of training adaptation in humans

AU - Gaesser, Glenn

AU - Poole, D. C.

PY - 1988

Y1 - 1988

N2 - We determined the time course of adaptation in blood lactate concentration ([La]) during constant-load exercise in response to training. Thirteen healthy subjects (11 males, 2 females) exercised on a cycle ergometer for 30 min/day at a work rate calculated to elicit 70% of pre-training V̇O2max, 6 days/week for 3 weeks. V̇O2max and blood [La] during constant-load exercise (training work rate) were determined at the end of each week of training. Training increased V̇O2max 8.5% (from 48.2 ± 1.5 ml·kg-1·min-1 pre-training to 52.3 ± 1.4 ml·kg-1·min-1 post-training, P < 0.01) and decreased constant-load blood [La] 53% (from 7.8 ± 0.6 mM pre-training to 3.7 ± 0.3 mM post-training, P < 0.01). The training-induced reduction in exercise blood [La] was well fit to an exponential (5.5 e((-t/2.2)) + 2.3, r = 0.99) with a half-time of 10.7 days. However, this was not the case for the time course of V̇O2max adaptation. The absolute decrease in blood [La] was correlated with the initial blood [La] (r = 0.88, P < 0.01), but changes in V̇O2max were not significantly correlated with initial blood [La] (r = -0.14) nor with changes in blood [La] (r = -0.02). We conclude that (1) blood [La] response to constant-load exercise decreases rapidly and exponentially with training, with a t( 1/2 ) of 10.7 days, (2) the magnitude of training adaptation is positively related to the initial blood [La], and (3) the time course and extent of the training-induced adaptations of blood [La] and V̇O2max appear to be independent of one another.

AB - We determined the time course of adaptation in blood lactate concentration ([La]) during constant-load exercise in response to training. Thirteen healthy subjects (11 males, 2 females) exercised on a cycle ergometer for 30 min/day at a work rate calculated to elicit 70% of pre-training V̇O2max, 6 days/week for 3 weeks. V̇O2max and blood [La] during constant-load exercise (training work rate) were determined at the end of each week of training. Training increased V̇O2max 8.5% (from 48.2 ± 1.5 ml·kg-1·min-1 pre-training to 52.3 ± 1.4 ml·kg-1·min-1 post-training, P < 0.01) and decreased constant-load blood [La] 53% (from 7.8 ± 0.6 mM pre-training to 3.7 ± 0.3 mM post-training, P < 0.01). The training-induced reduction in exercise blood [La] was well fit to an exponential (5.5 e((-t/2.2)) + 2.3, r = 0.99) with a half-time of 10.7 days. However, this was not the case for the time course of V̇O2max adaptation. The absolute decrease in blood [La] was correlated with the initial blood [La] (r = 0.88, P < 0.01), but changes in V̇O2max were not significantly correlated with initial blood [La] (r = -0.14) nor with changes in blood [La] (r = -0.02). We conclude that (1) blood [La] response to constant-load exercise decreases rapidly and exponentially with training, with a t( 1/2 ) of 10.7 days, (2) the magnitude of training adaptation is positively related to the initial blood [La], and (3) the time course and extent of the training-induced adaptations of blood [La] and V̇O2max appear to be independent of one another.

UR - http://www.scopus.com/inward/record.url?scp=0023718595&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023718595&partnerID=8YFLogxK

M3 - Article

C2 - 3182159

AN - SCOPUS:0023718595

VL - 9

SP - 284

EP - 288

JO - International Journal of Sports Medicine

JF - International Journal of Sports Medicine

SN - 0172-4622

IS - 4

ER -