Blood contamination and the measurement of salivary progesterone and estradiol

Katie T. Kivlighan; Douglas A. Granger; Eve B. Schwartz

doi:10.1016/j.yhbeh.2004.12.001

Blood contamination and the measurement of salivary progesterone and estradiol

Katie T. Kivlighan, Douglas A. Granger, Eve B. Schwartz

Psychology

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

The impact of blood leakage due to microinjury to the oral cavity on the measurement of salivary reproductive hormones was examined. Saliva samples were collected before, immediately after, and then every 15 min for 1 h following vigorous tooth brushing. Blood in saliva was quantified by visual inspection of discoloration and an immunoassay for transferrin. Levels of progesterone increased, and levels of estradiol decreased, in saliva after microinjury. These changes were present only immediately after microinjury. The findings have implications for the use of salivary assays in biobehavioral research, short-term dynamic investigations, pharmacokinetic analyses, and studies of chronobiological changes in progesterone and estradiol levels.

Original language	English (US)
Pages (from-to)	367-370
Number of pages	4
Journal	Hormones and Behavior
Volume	47
Issue number	3
DOIs	https://doi.org/10.1016/j.yhbeh.2004.12.001
State	Published - Mar 2005

Keywords

Blood contamination
Estradiol
Progesterone
Salivary biomarker
Transferrin

ASJC Scopus subject areas

Endocrinology
Endocrine and Autonomic Systems
Behavioral Neuroscience

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10.1016/j.yhbeh.2004.12.001

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abstract = "The impact of blood leakage due to microinjury to the oral cavity on the measurement of salivary reproductive hormones was examined. Saliva samples were collected before, immediately after, and then every 15 min for 1 h following vigorous tooth brushing. Blood in saliva was quantified by visual inspection of discoloration and an immunoassay for transferrin. Levels of progesterone increased, and levels of estradiol decreased, in saliva after microinjury. These changes were present only immediately after microinjury. The findings have implications for the use of salivary assays in biobehavioral research, short-term dynamic investigations, pharmacokinetic analyses, and studies of chronobiological changes in progesterone and estradiol levels.",

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AU - Granger, Douglas A.

AU - Schwartz, Eve B.

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AB - The impact of blood leakage due to microinjury to the oral cavity on the measurement of salivary reproductive hormones was examined. Saliva samples were collected before, immediately after, and then every 15 min for 1 h following vigorous tooth brushing. Blood in saliva was quantified by visual inspection of discoloration and an immunoassay for transferrin. Levels of progesterone increased, and levels of estradiol decreased, in saliva after microinjury. These changes were present only immediately after microinjury. The findings have implications for the use of salivary assays in biobehavioral research, short-term dynamic investigations, pharmacokinetic analyses, and studies of chronobiological changes in progesterone and estradiol levels.

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KW - Estradiol

KW - Progesterone

KW - Salivary biomarker

KW - Transferrin

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Blood contamination and the measurement of salivary progesterone and estradiol

Abstract

Keywords

ASJC Scopus subject areas

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