Bleomycin group antitumor agents

Research output: Chapter in Book/Report/Conference proceedingChapter

15 Scopus citations

Abstract

The bleomycins are structurally related antitumor antibiotics first isolated from Streptomyces verticillus as Cu(II) chelates by Umezawa and his colleagues. As illustrated in Figure 19.1, the bleomycins may be considered to be glycosylated oligopeptide-derived species, albeit composed of some rather unusual amino acid constituents. Some of these may actually be derived biosynthetically from proteinogenic amino acids, such as the bithiazole moiety, which is apparently formed by dehydrative cyclization and oxidation of β-alanylcysteinylcysteine. However, recent studies have revealed that the biosynthesis also depends in part on transformations used to assemble polyketide antibiotics.

Original languageEnglish (US)
Title of host publicationAnticancer Agents from Natural Products
PublisherCRC Press
Pages357-382
Number of pages26
ISBN (Electronic)9781420039658
ISBN (Print)9780849318634
StatePublished - Jan 1 2005
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)

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  • Cite this

    Hecht, S. M. (2005). Bleomycin group antitumor agents. In Anticancer Agents from Natural Products (pp. 357-382). CRC Press.