Biscoumarin derivatives from Edgeworthia gardneri that inhibit the lyase activity of DNA polymerase β

Shi Sheng Li, Zhijie Gao, Xizhi Feng, Sidney M. Hecht

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Bioassay-guided fractionation of an active methyl ethyl ketone extract of Edgeworthia gardneri, using an assay to monitor DNA polymerase β lyase inhibition, resulted in the isolation of three known biscoumarin derivatives, 7-hydroxy-3,7′-dicoumaryl ether (edgeworin, 1), 7-hydroxy-6-methoxy-3, 7′-dicoumaryl ether (daphnoretin, 2), and 6,7-dihydroxy-3,7′- dicoumaryl ether (edgeworthin, 3). Compounds 1-3 inhibited the lyase activity of DNA polymerase β with IC50 values of 7.3 μg/mL (22.5 μM), 43.0 μg/mL (122.3 μM), and 32.1 μg/mL (94.8 μM), respectively.

Original languageEnglish (US)
Pages (from-to)1608-1610
Number of pages3
JournalJournal of Natural Products
Volume67
Issue number9
DOIs
StatePublished - Sep 1 2004
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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