Bis-5-alkylresorcinols from Panopsis rubescens that inhibit DNA polymerase β

Jing Zhen Deng, Shelley R. Starck, Sidney M. Hecht

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Bioassay-guided fractionation of Panopsis rubescens, using an assay to detect DNA polymerase β inhibition, led to the isolation of two new bis-5- alkylresorcinols (1 and 2), in addition to one known bis-5-alkylresorcinol (3). The structures of 1-3 were established as 1,3-dihydroxy-5-[14'-(3,5- dihydroxyphenyl)-cis-4'tetradecenyl]benzene (1), 1,3-dihydroxy-5-[14'- (3,5-dihydroxyphenyl)-cis-7'-tetradecenyl]benzene (2), and 1,3-dihydroxy- 5-[14'-(3,5-dihydroxyphenyl)tetradecenyl]benzene (3), respectively, by spectroscopic and chemical analyses. Compounds 1-3 exhibited potent inhibition of calf thymus DNA polymerase β, with IC50 values of 7.5, 6.5, and 5.8 μM, respectively.

Original languageEnglish (US)
Pages (from-to)477-480
Number of pages4
JournalJournal of Natural Products
Volume62
Issue number3
DOIs
StatePublished - Mar 1999
Externally publishedYes

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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