Biosynthetic product molecular weight determinations by solution phase secondary ion mass spectrometry employing group 1a metal salts

Cedric W. Holzapfel, George Pettit, Gordon M. Cragg

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Sulfolane was found to be an excellent solvent for solution phase SIMS mass measurements of natural products employing group 1A metal iodides for molecular ion complex enhancement. Lithium iodide generally afforded maximum molecular ion complex formation. Although this very important effect was found to decrease through the series sodium→potassium→rubidium→cesium iodides, it remained quite useful. The 85Rb and 87Rb isotopes (ratio of 72:28) proved especially effective for detection of molecular ions and recognizing other metalcomplex ions. A mixture of lithium and sodium iodides was also found helpful for the latter purpose. Application of, e.g., the sodium iodide-sulfolane technique for increasing the intensity of molecular ion complexes proved to be a very simple and reliable method for conducting natural product molecular weight determinations.

Original languageEnglish (US)
Pages (from-to)513-522
Number of pages10
JournalJournal of Natural Products
Volume48
Issue number4
DOIs
StatePublished - Jul 1985

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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