Bioreactor technologies to support liver function in vitro

Mohammad R. Ebrahimkhani, Jaclyn A.Shepard Neiman, Micha Sam B. Raredon, David J. Hughes, Linda G. Griffith

Research output: Contribution to journalReview article

81 Scopus citations

Abstract

Liver is a central nexus integrating metabolic and immunologic homeostasis in the human body, and the direct or indirect target of most molecular therapeutics. A wide spectrum of therapeutic and technological needs drives efforts to capture liver physiology and pathophysiology in vitro, ranging from prediction of metabolism and toxicity of small molecule drugs, to understanding off-target effects of proteins, nucleic acid therapies, and targeted therapeutics, to serving as disease models for drug development. Here we provide perspective on the evolving landscape of bioreactor-based models to meet old and new challenges in drug discovery and development, emphasizing design challenges in maintaining long-term liver-specific function and how emerging technologies in biomaterials and microdevices are providing new experimental models.

Original languageEnglish (US)
Pages (from-to)132-157
Number of pages26
JournalAdvanced Drug Delivery Reviews
Volume69-70
DOIs
StatePublished - Jan 1 2014

Keywords

  • Bioreactor
  • Drug development
  • Drug toxicity
  • Hepatocytes
  • Liver non-parenchymal cells
  • Microfluidic
  • Organ on chip
  • Tissue engineering

ASJC Scopus subject areas

  • Pharmaceutical Science

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    Ebrahimkhani, M. R., Neiman, J. A. S., Raredon, M. S. B., Hughes, D. J., & Griffith, L. G. (2014). Bioreactor technologies to support liver function in vitro. Advanced Drug Delivery Reviews, 69-70, 132-157. https://doi.org/10.1016/j.addr.2014.02.011