TY - JOUR
T1 - Biomotors, viral assembly, and RNA nanobiotechnology
T2 - Current achievements and future directions
AU - Rolband, Lewis
AU - Beasock, Damian
AU - Wang, Yang
AU - Shu, Yao Gen
AU - Dinman, Jonathan D.
AU - Schlick, Tamar
AU - Zhou, Yaoqi
AU - Kieft, Jeffrey S.
AU - Chen, Shi Jie
AU - Bussi, Giovanni
AU - Oukhaled, Abdelghani
AU - Gao, Xingfa
AU - Šulc, Petr
AU - Binzel, Daniel
AU - Bhullar, Abhjeet S.
AU - Liang, Chenxi
AU - Guo, Peixuan
AU - Afonin, Kirill A.
N1 - Funding Information:
Y. W. and Y-G. S. thank Research Fund of Wenzhou Institute, UCAS (Grants No. WIUCASQD2020009, WIUCASQD2021043). S-J. C. thanks Dr. Yuanzhe Zhou for the help with plotting the figures. This work was supported by the National Institutes of Health under Grant R35-GM134919. Research reported in this publication was supported by the National Institute of General Medical Sciences of the National Institutes of Health under Award Number R35GM139587 (to K.A.A.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. T. S. gratefully acknowledges funding from the National Science Foundation RAPID Award 2030377 and DMS-2151777 and from the National Institutes of Health/NIGMS Award R35GM122562.
Publisher Copyright:
© 2022
PY - 2022/1
Y1 - 2022/1
N2 - The International Society of RNA Nanotechnology and Nanomedicine (ISRNN) serves to further the development of a wide variety of functional nucleic acids and other related nanotechnology platforms. To aid in the dissemination of the most recent advancements, a biennial discussion focused on biomotors, viral assembly, and RNA nanobiotechnology has been established where international experts in interdisciplinary fields such as structural biology, biophysical chemistry, nanotechnology, cell and cancer biology, and pharmacology share their latest accomplishments and future perspectives. The results summarized here highlight advancements in our understanding of viral biology and the structure–function relationship of frame-shifting elements in genomic viral RNA, improvements in the predictions of SHAPE analysis of 3D RNA structures, and the understanding of dynamic RNA structures through a variety of experimental and computational means. Additionally, recent advances in the drug delivery, vaccine design, nanopore technologies, biomotor and biomachine development, DNA packaging, RNA nanotechnology, and drug delivery are included in this critical review. We emphasize some of the novel accomplishments, major discussion topics, and present current challenges and perspectives of these emerging fields.
AB - The International Society of RNA Nanotechnology and Nanomedicine (ISRNN) serves to further the development of a wide variety of functional nucleic acids and other related nanotechnology platforms. To aid in the dissemination of the most recent advancements, a biennial discussion focused on biomotors, viral assembly, and RNA nanobiotechnology has been established where international experts in interdisciplinary fields such as structural biology, biophysical chemistry, nanotechnology, cell and cancer biology, and pharmacology share their latest accomplishments and future perspectives. The results summarized here highlight advancements in our understanding of viral biology and the structure–function relationship of frame-shifting elements in genomic viral RNA, improvements in the predictions of SHAPE analysis of 3D RNA structures, and the understanding of dynamic RNA structures through a variety of experimental and computational means. Additionally, recent advances in the drug delivery, vaccine design, nanopore technologies, biomotor and biomachine development, DNA packaging, RNA nanotechnology, and drug delivery are included in this critical review. We emphasize some of the novel accomplishments, major discussion topics, and present current challenges and perspectives of these emerging fields.
KW - Biomotors
KW - Drug delivery
KW - ISRNN
KW - RNA nanotechnology
KW - Therapies
KW - Virus assembly
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U2 - 10.1016/j.csbj.2022.11.007
DO - 10.1016/j.csbj.2022.11.007
M3 - Review article
AN - SCOPUS:85141914601
SN - 2001-0370
VL - 20
SP - 6120
EP - 6137
JO - Computational and Structural Biotechnology Journal
JF - Computational and Structural Biotechnology Journal
ER -