Biomechatronic fluid sample handling system for DNA processing

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

An automated biomechatronic small fluid sample preparation system for DNA processing has been developed in the Genomation Laboratory of the University of Washington Department of Electrical Engineering. The system automates steps necessary to prepare DNA for sequencing using sample volumes ten times smaller than the current state of the art manual and automated instrumentation. This will significantly reduce the time and cost of DNA sequencing and will help the Human Genome Project meet its goal of determining all three billion bases of human DNA sequence by the year 2005. The biomechatronic system comprising electromagnetic actuators, piezoceramic actuators, pneumatic pumps, linear mechanisms, thermal controllers, optical sensors, electronics, computer control and software is described in detail. Successful experimental results including restriction enzyme digests and polymerase chain reactions (PCRs) performed with this novel system are presented.

Original languageEnglish (US)
Title of host publicationIEEE/ASME International Conference on Advanced Intelligent Mechatronics, AIM
Place of PublicationPiscataway, NJ, United States
PublisherIEEE
Pages6
Number of pages1
StatePublished - 1997
Externally publishedYes
EventProceedings of the 1997 1st IEEE/ASME International Conference on Advanced Intelligent Mechatronics, AIM'97 - Tokyo, Jpn
Duration: Jun 16 1997Jun 20 1997

Other

OtherProceedings of the 1997 1st IEEE/ASME International Conference on Advanced Intelligent Mechatronics, AIM'97
CityTokyo, Jpn
Period6/16/976/20/97

ASJC Scopus subject areas

  • Engineering(all)

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