Biological and Behavioral Markers of Alcohol Sensitivity

Kim Fromme, Harriet De Wit, Kent E. Hutchison, Lara Ray, William Corbin, Travis A R Cook, Tamara L. Wall, David Goldman

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

This article summarizes a symposium that was organized by Dr. Kim Fromme and presented at the 2003 annual meeting of the Research Society on Alcoholism in Ft. Lauderdale, Florida. The four presentations illustrate the emerging technologies and methods that are now being used to investigate the genetic basis of differential sensitivity to alcohol and their behavioral manifestations. Combining human genotyping with laboratory measures of behavior and subjective reports, these presentations represent state-of-the-art approaches to crossing the bridge from the Decade of the Brain to the Decade of Behavior. Dr. De Wit's paper describes her research on the neurobiological basis for individual differences in sensitivity to the stimulant and sedative effects of alcohol. Evidence suggests that activity of the dopaminergic and GABAergic neurotransmitters underlie these stimulant and sedative effects, respectively. Both Drs. Hutchison's and Corbin's papers describe their research on polymorphisms for the serotonin transporter (SLC6A4) as a determinant of the subjective effects of alcohol challenge. Dr. Hutchinson's and Ms. Ray's findings indicate that individuals with the short form of the SLC6A4 alleles (S) demonstrated a low level of response to alcohol, thus supporting previous research that the S allele may be associated with increased risk for alcohol dependence. In contrast, Dr. Corbin did not find a reliable association between the SLC6A4 genotype and subjective response to alcohol. Mr. Cook's and Dr. Wall's paper adds another dimension to this article by presenting research on both the aldehyde dehydrogenase (ALDH2) and alcohol dehydrogenase (ADH2) genetic variants and their association with the alcohol-related flushing response that is prevalent in Asian populations. Dr. David Goldman provides concluding remarks.

Original languageEnglish (US)
Pages (from-to)247-256
Number of pages10
JournalAlcoholism: Clinical and Experimental Research
Volume28
Issue number2
DOIs
StatePublished - Feb 2004
Externally publishedYes

Fingerprint

Biomarkers
Alcohols
Hypnotics and Sedatives
Research
Alleles
Serotonin Plasma Membrane Transport Proteins
Aldehyde Dehydrogenase
Wit and Humor
Alcohol Dehydrogenase
Individuality
Alcoholism
Neurotransmitter Agents
Polymorphism
Genotype
Brain
Technology
Population

Keywords

  • ADH2
  • Alcohol Sensitivity
  • ALDH2
  • GABA
  • Serotonin

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

Fromme, K., De Wit, H., Hutchison, K. E., Ray, L., Corbin, W., Cook, T. A. R., ... Goldman, D. (2004). Biological and Behavioral Markers of Alcohol Sensitivity. Alcoholism: Clinical and Experimental Research, 28(2), 247-256. https://doi.org/10.1097/01.ALC.0000113420.28472.25

Biological and Behavioral Markers of Alcohol Sensitivity. / Fromme, Kim; De Wit, Harriet; Hutchison, Kent E.; Ray, Lara; Corbin, William; Cook, Travis A R; Wall, Tamara L.; Goldman, David.

In: Alcoholism: Clinical and Experimental Research, Vol. 28, No. 2, 02.2004, p. 247-256.

Research output: Contribution to journalArticle

Fromme, K, De Wit, H, Hutchison, KE, Ray, L, Corbin, W, Cook, TAR, Wall, TL & Goldman, D 2004, 'Biological and Behavioral Markers of Alcohol Sensitivity', Alcoholism: Clinical and Experimental Research, vol. 28, no. 2, pp. 247-256. https://doi.org/10.1097/01.ALC.0000113420.28472.25
Fromme, Kim ; De Wit, Harriet ; Hutchison, Kent E. ; Ray, Lara ; Corbin, William ; Cook, Travis A R ; Wall, Tamara L. ; Goldman, David. / Biological and Behavioral Markers of Alcohol Sensitivity. In: Alcoholism: Clinical and Experimental Research. 2004 ; Vol. 28, No. 2. pp. 247-256.
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