Biologic characteristics of premalignant breast disease

Kimberly Cole, Maria Tabernero, Karen Anderson

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Breast cancer is the second leading cause of cancer death in women in the United States. While mammography and breast magnetic resonance imaging (MRI) improve detection of early disease, there remains an unmet need for biomarkers for risk stratification, early detection, prediction, and disease prognosis. A number of early breast lesions, from atypical hyperplasias to carcinomas in situ, are associated with an increased risk of developing subsequent invasive breast carcinoma. The recent development of genomic, epigenomic, and proteomic tools for tissue biomarker detection, including array CGH, RNA expression microarrays, and proteomic arrays have identified a number of potential biomarkers that both identify patients at increased risk, as well as provided insights into the pathology of early breast cancer development. This chapter focuses on the detection and application of tissue and serum biomarkers for the identification and risk stratification of early breast cancer lesions.

Original languageEnglish (US)
Pages (from-to)177-192
Number of pages16
JournalCancer Biomarkers
Volume9
Issue number1-6
DOIs
StatePublished - 2011
Externally publishedYes

Fingerprint

Breast Diseases
Biomarkers
Breast Neoplasms
Proteomics
Early Diagnosis
Breast
Carcinoma in Situ
Mammography
Epigenomics
Hyperplasia
Cause of Death
Magnetic Resonance Imaging
RNA
Pathology
Serum
Neoplasms

Keywords

  • benign breast disease
  • biomarkers
  • Breast cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Genetics

Cite this

Biologic characteristics of premalignant breast disease. / Cole, Kimberly; Tabernero, Maria; Anderson, Karen.

In: Cancer Biomarkers, Vol. 9, No. 1-6, 2011, p. 177-192.

Research output: Contribution to journalArticle

Cole, Kimberly ; Tabernero, Maria ; Anderson, Karen. / Biologic characteristics of premalignant breast disease. In: Cancer Biomarkers. 2011 ; Vol. 9, No. 1-6. pp. 177-192.
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