Biologic characteristics of premalignant breast disease

Kimberly Cole, Maria Tabernero, Karen S. Anderson

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Breast cancer is the second leading cause of cancer death in women in the United States. While mammography and breast magnetic resonance imaging (MRI) improve detection of early disease, there remains an unmet need for biomarkers for risk stratification, early detection, prediction, and disease prognosis. A number of early breast lesions, from atypical hyperplasias to carcinomas in situ, are associated with an increased risk of developing subsequent invasive breast carcinoma. The recent development of genomic, epigenomic, and proteomic tools for tissue biomarker detection, including array CGH, RNA expression microarrays, and proteomic arrays have identified a number of potential biomarkers that both identify patients at increased risk, as well as provided insights into the pathology of early breast cancer development. This chapter focuses on the detection and application of tissue and serum biomarkers for the identification and risk stratification of early breast cancer lesions.

Original languageEnglish (US)
Pages (from-to)177-192
Number of pages16
JournalCancer Biomarkers
Volume9
Issue number1-6
DOIs
StatePublished - Dec 12 2011

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Keywords

  • Breast cancer
  • benign breast disease
  • biomarkers

ASJC Scopus subject areas

  • Oncology
  • Genetics
  • Cancer Research

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