Bioinspired core-crosslinked micelles from thymine-functionalized amphiphilic block copolymers: Hydrogen bonding and photo-crosslinking study

Gagan Kaur; Shery L.Y. Chang; Toby D.M. Bell; Milton T.W. Hearn; Kei Saito

doi:10.1002/pola.24853

Bioinspired core-crosslinked micelles from thymine-functionalized amphiphilic block copolymers: Hydrogen bonding and photo-crosslinking study

Gagan Kaur, Shery L.Y. Chang, Toby D.M. Bell, Milton T.W. Hearn, Kei Saito

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Bioinspired core-bound polymeric micelles, based on hydrogen bonding and photo-crosslinking, of thymine have been prepared from poly(vinylbenzylthymine)- b-poly(vinylbenzyltriethylammonium chloride). The amphiphilic block copolymer was synthesized by 2,2-tetramethylpiperidin-1-oxyl-mediated living radical polymerization in water/ethylene glycol solution. Micelle characterization and critical micelle concentration measurements demonstrated that the hydrogen bonding of the attached thymine units stabilizes the micelles. Further, core-crosslinked polymeric micelles were formed by ultraviolet (UV) radiation showing that the stability of the micelle could be controlled by the UV crosslinking of the attached thymines.

Original language	English (US)
Pages (from-to)	4121-4128
Number of pages	8
Journal	Journal of Polymer Science, Part A: Polymer Chemistry
Volume	49
Issue number	19
DOIs	https://doi.org/10.1002/pola.24853
State	Published - Oct 1 2011
Externally published	Yes

Keywords

biomimetic
block copolymer
core-shell polymers

ASJC Scopus subject areas

Polymers and Plastics
Organic Chemistry
Materials Chemistry

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10.1002/pola.24853

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title = "Bioinspired core-crosslinked micelles from thymine-functionalized amphiphilic block copolymers: Hydrogen bonding and photo-crosslinking study",

abstract = "Bioinspired core-bound polymeric micelles, based on hydrogen bonding and photo-crosslinking, of thymine have been prepared from poly(vinylbenzylthymine)- b-poly(vinylbenzyltriethylammonium chloride). The amphiphilic block copolymer was synthesized by 2,2-tetramethylpiperidin-1-oxyl-mediated living radical polymerization in water/ethylene glycol solution. Micelle characterization and critical micelle concentration measurements demonstrated that the hydrogen bonding of the attached thymine units stabilizes the micelles. Further, core-crosslinked polymeric micelles were formed by ultraviolet (UV) radiation showing that the stability of the micelle could be controlled by the UV crosslinking of the attached thymines.",

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T2 - Hydrogen bonding and photo-crosslinking study

AU - Kaur, Gagan

AU - Chang, Shery L.Y.

AU - Bell, Toby D.M.

AU - Hearn, Milton T.W.

AU - Saito, Kei

PY - 2011/10/1

Y1 - 2011/10/1

N2 - Bioinspired core-bound polymeric micelles, based on hydrogen bonding and photo-crosslinking, of thymine have been prepared from poly(vinylbenzylthymine)- b-poly(vinylbenzyltriethylammonium chloride). The amphiphilic block copolymer was synthesized by 2,2-tetramethylpiperidin-1-oxyl-mediated living radical polymerization in water/ethylene glycol solution. Micelle characterization and critical micelle concentration measurements demonstrated that the hydrogen bonding of the attached thymine units stabilizes the micelles. Further, core-crosslinked polymeric micelles were formed by ultraviolet (UV) radiation showing that the stability of the micelle could be controlled by the UV crosslinking of the attached thymines.

AB - Bioinspired core-bound polymeric micelles, based on hydrogen bonding and photo-crosslinking, of thymine have been prepared from poly(vinylbenzylthymine)- b-poly(vinylbenzyltriethylammonium chloride). The amphiphilic block copolymer was synthesized by 2,2-tetramethylpiperidin-1-oxyl-mediated living radical polymerization in water/ethylene glycol solution. Micelle characterization and critical micelle concentration measurements demonstrated that the hydrogen bonding of the attached thymine units stabilizes the micelles. Further, core-crosslinked polymeric micelles were formed by ultraviolet (UV) radiation showing that the stability of the micelle could be controlled by the UV crosslinking of the attached thymines.

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KW - block copolymer

KW - core-shell polymers

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Bioinspired core-crosslinked micelles from thymine-functionalized amphiphilic block copolymers: Hydrogen bonding and photo-crosslinking study

Abstract

Keywords

ASJC Scopus subject areas

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