Bioinspired core-crosslinked micelles from thymine-functionalized amphiphilic block copolymers: Hydrogen bonding and photo-crosslinking study

Gagan Kaur, Shery L.Y. Chang, Toby D.M. Bell, Milton T.W. Hearn, Kei Saito

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Bioinspired core-bound polymeric micelles, based on hydrogen bonding and photo-crosslinking, of thymine have been prepared from poly(vinylbenzylthymine)- b-poly(vinylbenzyltriethylammonium chloride). The amphiphilic block copolymer was synthesized by 2,2-tetramethylpiperidin-1-oxyl-mediated living radical polymerization in water/ethylene glycol solution. Micelle characterization and critical micelle concentration measurements demonstrated that the hydrogen bonding of the attached thymine units stabilizes the micelles. Further, core-crosslinked polymeric micelles were formed by ultraviolet (UV) radiation showing that the stability of the micelle could be controlled by the UV crosslinking of the attached thymines.

Original languageEnglish (US)
Pages (from-to)4121-4128
Number of pages8
JournalJournal of Polymer Science, Part A: Polymer Chemistry
Volume49
Issue number19
DOIs
StatePublished - Oct 1 2011
Externally publishedYes

Keywords

  • biomimetic
  • block copolymer
  • core-shell polymers

ASJC Scopus subject areas

  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

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