Biofilms and the plasmid maintenance question

Mudassar Imran, Donald Jones, Hal Smith

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Can a conjugative plasmid encoding enhanced biofilm forming abilities for its bacterial host facilitate the persistence of the plasmid in a bacterial population despite conferring diminished growth rate and segregative plasmid loss on its bearers? We construct a mathematical model in a chemostat and in a plug flow environment to answer this question. Explicit conditions for an affirmative answer are derived. Numerical simulations support the conclusion.

Original languageEnglish (US)
Pages (from-to)183-204
Number of pages22
JournalMathematical Biosciences
Volume193
Issue number2
DOIs
StatePublished - Feb 1 2005

Keywords

  • Bacterial wall growth
  • Biofilm
  • Chemostat
  • Conjugation
  • Model
  • Plasmid
  • Plug flow
  • Segregation

ASJC Scopus subject areas

  • Statistics and Probability
  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

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