Biofilms and the plasmid maintenance question

Mudassar Imran; Donald Jones; Hal Smith

doi:10.1016/j.mbs.2004.10.008

Biofilms and the plasmid maintenance question

Mudassar Imran, Donald Jones, Hal Smith

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Can a conjugative plasmid encoding enhanced biofilm forming abilities for its bacterial host facilitate the persistence of the plasmid in a bacterial population despite conferring diminished growth rate and segregative plasmid loss on its bearers? We construct a mathematical model in a chemostat and in a plug flow environment to answer this question. Explicit conditions for an affirmative answer are derived. Numerical simulations support the conclusion.

Original language	English (US)
Pages (from-to)	183-204
Number of pages	22
Journal	Mathematical Biosciences
Volume	193
Issue number	2
DOIs	https://doi.org/10.1016/j.mbs.2004.10.008
State	Published - Feb 1 2005

Keywords

Bacterial wall growth
Biofilm
Chemostat
Conjugation
Model
Plasmid
Plug flow
Segregation

ASJC Scopus subject areas

Statistics and Probability
Modeling and Simulation
General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology
General Agricultural and Biological Sciences
Applied Mathematics

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10.1016/j.mbs.2004.10.008

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abstract = "Can a conjugative plasmid encoding enhanced biofilm forming abilities for its bacterial host facilitate the persistence of the plasmid in a bacterial population despite conferring diminished growth rate and segregative plasmid loss on its bearers? We construct a mathematical model in a chemostat and in a plug flow environment to answer this question. Explicit conditions for an affirmative answer are derived. Numerical simulations support the conclusion.",

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AU - Jones, Donald

AU - Smith, Hal

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AB - Can a conjugative plasmid encoding enhanced biofilm forming abilities for its bacterial host facilitate the persistence of the plasmid in a bacterial population despite conferring diminished growth rate and segregative plasmid loss on its bearers? We construct a mathematical model in a chemostat and in a plug flow environment to answer this question. Explicit conditions for an affirmative answer are derived. Numerical simulations support the conclusion.

KW - Bacterial wall growth

KW - Biofilm

KW - Chemostat

KW - Conjugation

KW - Model

KW - Plasmid

KW - Plug flow

KW - Segregation

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JO - Mathematical Biosciences

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ER -

Biofilms and the plasmid maintenance question

Abstract

Keywords

ASJC Scopus subject areas

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