Biocompatible benzocyclobutene-based intracortical neural implant with surface modification

Keekeun Lee, Stephen Massia, Jiping He

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

This paper presents the fabrication of a benzocyclobutene (BCB) polymer-based intracortical neural implant for reliable and stable long-term implant function. BCB polymer has many attractive features for chronic implant application: flexibility, biocompatibility, low moisture uptake, low dielectric constant and easy surface modification. A 2 νm thick silicon backbone layer was attached underneath a flexible BCB electrode to improve mechanical stiffness. No insertion trauma was observed during penetrating into the dura of a rat. In vitro cytotoxicity tests of the completed BCB electrode revealed no toxic effects on cultured cells. The modified BCB surface with a dextran coating showed a significant reduction in 3T3 cell adhesion and spreading, indicating that this coating has the potential for lowering protein adsorption, minimizing inflammatory cell adhesion and glial scar formation in vivo, and thereby enhancing long-term implant performance.

Original languageEnglish (US)
Pages (from-to)2149-2155
Number of pages7
JournalJournal of Micromechanics and Microengineering
Volume15
Issue number11
DOIs
StatePublished - Nov 1 2005

Fingerprint

Cell adhesion
Surface treatment
adhesion
coatings
Coatings
scars
Electrodes
dextrans
Dextran
electrodes
polymers
biocompatibility
Polymers
Cytotoxicity
cells
Biocompatibility
cultured cells
moisture
rats
Rats

ASJC Scopus subject areas

  • Instrumentation
  • Materials Science(all)
  • Mechanics of Materials
  • Computational Mechanics

Cite this

Biocompatible benzocyclobutene-based intracortical neural implant with surface modification. / Lee, Keekeun; Massia, Stephen; He, Jiping.

In: Journal of Micromechanics and Microengineering, Vol. 15, No. 11, 01.11.2005, p. 2149-2155.

Research output: Contribution to journalArticle

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