Bioanalytical separations using electric field gradient techniques

Michelle M. Meighan, Sarah J R Staton, Mark Hayes

Research output: Contribution to journalReview articlepeer-review

58 Scopus citations

Abstract

The field of separations science will be strongly impacted by new electric-field-gradient-based strategies. Many new capabilities are being developed with analytical targets ranging from particles to small molecules, and soot to living cells. Here we review the emerging area of electric field gradient techniques, dividing the large variety of techniques by the target of separation. In doing so, we have contributions using dielectrophoresis, electric field gradient focusing (including dynamic, true moving bed, and pulsed field), electrocapture and electrophoretic focusing, temperature gradient focusing, and focusing with centrifugal force. We cover the literature from the start of 2007 to June 2008, along with some introductory discussions. Even with the relatively short time frame, this young and dynamic field of inquiry produced some 100 contributions describing new and unique techniques and several new applications.

Original languageEnglish (US)
Pages (from-to)852-865
Number of pages14
JournalElectrophoresis
Volume30
Issue number5
DOIs
StatePublished - Jun 2 2009

Keywords

  • Bioanalysis
  • Dielectrophoresis
  • Electric field gradient
  • Particles

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry

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