Bioactive DNA-peptide nanotubes enhance the differentiation of neural stem cells into neurons

Nicholas Stephanopoulos, Ronit Freeman, Hilary A. North, Shantanu Sur, Su Ji Jeong, Faifan Tantakitti, John A. Kessler, Samuel I. Stupp

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

We report the construction of DNA nanotubes covalently functionalized with the cell adhesion peptide RGDS as a bioactive substrate for neural stem cell differentiation. Alteration of the Watson-Crick base pairing program that builds the nanostructures allowed us to probe independently the effect of nanotube architecture and peptide bioactivity on stem cell differentiation. We found that both factors instruct synergistically the preferential differentiation of the cells into neurons rather than astrocytes.

Original languageEnglish (US)
Pages (from-to)603-609
Number of pages7
JournalNano Letters
Volume15
Issue number1
DOIs
StatePublished - Jan 14 2015

Keywords

  • DNA nanotechnology
  • DNA-peptide
  • Self-assembly
  • biomaterials
  • extracellular matrix
  • neural stem cells

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

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  • Cite this

    Stephanopoulos, N., Freeman, R., North, H. A., Sur, S., Jeong, S. J., Tantakitti, F., Kessler, J. A., & Stupp, S. I. (2015). Bioactive DNA-peptide nanotubes enhance the differentiation of neural stem cells into neurons. Nano Letters, 15(1), 603-609. https://doi.org/10.1021/nl504079q