Beneficial effects of U-63,557A, a thromboxane synthetase inhibitor in an ovine model of pregnancy-induced hypertension

J. C. Keith, Craig Thatcher, R. G. Schaub

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Pregnancy-induced hypertension was induced in five ewes (gestational day 135; term 150 days) by 72 hours of food deprivation. Maternal arterial pressure, uterine blood flow, platelet function, renal funtion, and plasma levels of 6-ketoprostaglandin F(1α) and thromboxane B2 were measured before and during hypertension and after three intravenous injections of U-63,557A; sodium 5-(3'-pyridinylmethyl) benzofuran-2-carboxylate, monohydrate (30 mg/kg every 8 hours). Blood pressure increased (p < 0.03), and returned to normal after U-63,557A. Left uterine artery blood flow increased after U-63,557A (p < 0.03). Creatinine clearance decreased during hypertension (p < 0.03) and increased after U-63,557A. Urine protein increased during hypertension (p < 0.03) and decreased after treatment. Platelet count dropped during hypertension (p < 0.03) and was elevated after treatment. Collagen lag phase decreased during hypertension (p < 0.03) and increased after treatment. After U-63,557A, 6-ketoprostaglandin F(1α) levels were higher (p < 0.04) than baseline or hypertensive values. Administration of a thromboxane synthetase inhibitor caused resulotion of hemodynamic, renal, and coagulation dysfunctions that occurred in ovine pregnancy-induced hypertension.

Original languageEnglish (US)
Pages (from-to)199-203
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume157
Issue number1
StatePublished - 1987
Externally publishedYes

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Thromboxane-A Synthase
Pregnancy Induced Hypertension
Sheep
Hypertension
Kidney
Food Deprivation
Uterine Artery
Thromboxane B2
Platelet Count
Intravenous Injections
Creatinine
Arterial Pressure
Collagen
Therapeutics
Blood Platelets
Hemodynamics
Mothers
Urine
Blood Pressure
Proteins

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Beneficial effects of U-63,557A, a thromboxane synthetase inhibitor in an ovine model of pregnancy-induced hypertension. / Keith, J. C.; Thatcher, Craig; Schaub, R. G.

In: American Journal of Obstetrics and Gynecology, Vol. 157, No. 1, 1987, p. 199-203.

Research output: Contribution to journalArticle

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