Beneficial effects of U-63 557A a thromboxane synthetase inhibitor, in an ovine model of pregnancy-induced hypertension

James C. Keith, Craig D. Thatcher, Robert G. Schaub

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Pregnancy-induced hypertension was induced in five ewes (gestational day 135; term 150 days) by 72 hours of food deprivation. Maternal arterial pressure, uterine blood flow, platelet function, renal function, and plasma levels of 6-ketoprostaglandin F and thromboxane B2 were measured before and during hypertension and after three intravenous injections of U-63,557A; sodium 5-(3′-pyridinylmethyl) benzofuran-2-carboxylate, monohydrate (30 mg/kg every 8 hours). Blood pressure increased (p < 0.03), and returned to normal after U-63,557A. Left uterine artery blood flow increased after U-63,557A (p < 0.03). Creatinine clearance decreased during hypertension (p < 0.03) and increased after U-63,557A. Urine protein increased during hypertension (p < 0.03) and decreased after treatment. Platelet count dropped during hypertension (p < 0.03) and was elevated after treatment. Collagen lag phase decreased during hypertension (p < 0.03) and increased after treatment. After U-63,557A, 6-ketoprostagland in F levels were higher (p < 0.04) than baseline or hypertensive values. Administration of a thromboxane synthetase inhibitor caused resolution of hemodynamic, renal, and coagulation dysfunctions that occurred in ovine pregnancy-induced hypertension.

Original languageEnglish (US)
Pages (from-to)199-203
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume157
Issue number1
DOIs
StatePublished - Jan 1 1987
Externally publishedYes

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Keywords

  • Pregnancy-induced hypertension
  • U-63,557A
  • sheep
  • thromboxane synthetase inhibitor

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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