TY - JOUR
T1 - Beneficial effects of U-63 557A a thromboxane synthetase inhibitor, in an ovine model of pregnancy-induced hypertension
AU - Keith, James C.
AU - Thatcher, Craig D.
AU - Schaub, Robert G.
PY - 1987/1/1
Y1 - 1987/1/1
N2 - Pregnancy-induced hypertension was induced in five ewes (gestational day 135; term 150 days) by 72 hours of food deprivation. Maternal arterial pressure, uterine blood flow, platelet function, renal function, and plasma levels of 6-ketoprostaglandin F1α and thromboxane B2 were measured before and during hypertension and after three intravenous injections of U-63,557A; sodium 5-(3′-pyridinylmethyl) benzofuran-2-carboxylate, monohydrate (30 mg/kg every 8 hours). Blood pressure increased (p < 0.03), and returned to normal after U-63,557A. Left uterine artery blood flow increased after U-63,557A (p < 0.03). Creatinine clearance decreased during hypertension (p < 0.03) and increased after U-63,557A. Urine protein increased during hypertension (p < 0.03) and decreased after treatment. Platelet count dropped during hypertension (p < 0.03) and was elevated after treatment. Collagen lag phase decreased during hypertension (p < 0.03) and increased after treatment. After U-63,557A, 6-ketoprostagland in F1α levels were higher (p < 0.04) than baseline or hypertensive values. Administration of a thromboxane synthetase inhibitor caused resolution of hemodynamic, renal, and coagulation dysfunctions that occurred in ovine pregnancy-induced hypertension.
AB - Pregnancy-induced hypertension was induced in five ewes (gestational day 135; term 150 days) by 72 hours of food deprivation. Maternal arterial pressure, uterine blood flow, platelet function, renal function, and plasma levels of 6-ketoprostaglandin F1α and thromboxane B2 were measured before and during hypertension and after three intravenous injections of U-63,557A; sodium 5-(3′-pyridinylmethyl) benzofuran-2-carboxylate, monohydrate (30 mg/kg every 8 hours). Blood pressure increased (p < 0.03), and returned to normal after U-63,557A. Left uterine artery blood flow increased after U-63,557A (p < 0.03). Creatinine clearance decreased during hypertension (p < 0.03) and increased after U-63,557A. Urine protein increased during hypertension (p < 0.03) and decreased after treatment. Platelet count dropped during hypertension (p < 0.03) and was elevated after treatment. Collagen lag phase decreased during hypertension (p < 0.03) and increased after treatment. After U-63,557A, 6-ketoprostagland in F1α levels were higher (p < 0.04) than baseline or hypertensive values. Administration of a thromboxane synthetase inhibitor caused resolution of hemodynamic, renal, and coagulation dysfunctions that occurred in ovine pregnancy-induced hypertension.
KW - Pregnancy-induced hypertension
KW - U-63,557A
KW - sheep
KW - thromboxane synthetase inhibitor
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U2 - 10.1016/S0002-9378(87)80380-0
DO - 10.1016/S0002-9378(87)80380-0
M3 - Article
C2 - 3605254
AN - SCOPUS:0023259794
SN - 0002-9378
VL - 157
SP - 199
EP - 203
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 1
ER -