Behavioural manifestations and associated non-motor features of freezing of gait: A narrative review and theoretical framework

Kaylena A. Ehgoetz Martens, Daniel S. Peterson, Quincy J. Almeida, Simon J.G. Lewis, Jeffrey M. Hausdorff, Alice Nieuwboer

Research output: Contribution to journalReview article

Abstract

Over the past decade, non-motor related symptoms and provocative contexts have offered unique opportunities to gain insight into the potential mechanisms that may underpin freezing of gait (FOG) in Parkinson's disease (PD). While this large body of work has informed several theoretical models, to date, few are capable of explaining behavioural findings across multiple domains (i.e. cognitive, sensory-perceptual and affective) and in different behavorial contexts. As such, the exact nature of these interrelationships and their neural basis remain quite enigmatic. Here, the non-motor, behavioural evidence for cognitive, sensory-perceptual and affective contributors to FOG are reviewed and synthesized by systematically examining (i) studies that manipulated contextual environments that provoke freezing of gait, (ii) studies that uncovered factors that have been proposed to contribute to freezing, and (iii) studies that longitudinally tracked factors that predict the future development of freezing of gait. After consolidating the evidence, we offer a novel perspective for integrating these multi-faceted behavioural patterns and identify key challenges that warrant consideration in future work.

Original languageEnglish (US)
Pages (from-to)350-364
Number of pages15
JournalNeuroscience and Biobehavioral Reviews
Volume116
DOIs
StatePublished - Sep 2020

Keywords

  • Affective
  • Cognitive
  • Freezing of gait
  • Parkinson's disease
  • Sensorimotor

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Fingerprint Dive into the research topics of 'Behavioural manifestations and associated non-motor features of freezing of gait: A narrative review and theoretical framework'. Together they form a unique fingerprint.

  • Cite this