Behavioural characterization of the anorexic effect of naloxone in domestic pigeons

P. Deviche, A. Wohland

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Satiated pigeons received intramuscular injections of the opiate antagonist naloxone HCl at 4 doses (0, 0.5, 1, or 2 mg) and their food consumption was monitored for 20 min., starting 15 min. after the treatments. As compared with the control injection, each dose of the drug attenuated the consumption of food. The effect occurred from the 2nd (0.5 mg) or 1st (higher doses) min. post food-delivery. Together with previous studies using opiate antagonists in pigeons and other species, these results suggest that naloxone produces anorexia by acting on pre- rather than post-ingestive factors. The mechanism of action of the drug on feeding could namely consist in (a) an alteration of a central satiety mechanism and (or) (b) a changed reactivity of the subjects to food palatability.

Original languageEnglish (US)
Pages (from-to)427-428
Number of pages2
JournalIRCS Medical Science
Volume12
Issue number5
StatePublished - Jan 1 1984
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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