Satiated pigeons received intramuscular injections of the opiate antagonist naloxone HCl at 4 doses (0, 0.5, 1, or 2 mg) and their food consumption was monitored for 20 min., starting 15 min. after the treatments. As compared with the control injection, each dose of the drug attenuated the consumption of food. The effect occurred from the 2nd (0.5 mg) or 1st (higher doses) min. post food-delivery. Together with previous studies using opiate antagonists in pigeons and other species, these results suggest that naloxone produces anorexia by acting on pre- rather than post-ingestive factors. The mechanism of action of the drug on feeding could namely consist in (a) an alteration of a central satiety mechanism and (or) (b) a changed reactivity of the subjects to food palatability.
|Original language||English (US)|
|Number of pages||2|
|Journal||IRCS Medical Science|
|State||Published - Jan 1 1984|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)