Behavioral genomics of honeybee foraging and nest defense

Greg J. Hunt, Gro Amdam, David Schlipalius, Christine Emore, Nagesh Sardesai, Christie E. Williams, Olav Rueppell, Ernesto Guzmán-Novoa, Miguel Arechavaleta-Velasco, Sathees Chandra, M. Kim Fondrk, Martin Beye, Robert Page

Research output: Contribution to journalArticle

131 Citations (Scopus)

Abstract

The honeybee has been the most important insect species for study of social behavior. The recently released draft genomic sequence for the bee will accelerate honeybee behavioral genetics. Although we lack sufficient tools to manipulate this genome easily, quantitative trait loci (QTLs) that influence natural variation in behavior have been identified and tested for their effects on correlated behavioral traits. We review what is known about the genetics and physiology of two behavioral traits in honeybees, foraging specialization (pollen versus nectar), and defensive behavior, and present evidence that map-based cloning of genes is more feasible in the bee than in other metazoans. We also present bioinformatic analyses of candidate genes within QTL confidence intervals (CIs). The high recombination rate of the bee made it possible to narrow the search to regions containing only 17-61 predicted peptides for each QTL, although CIs covered large genetic distances. Knowledge of correlated behavioral traits, comparative bioinformatics, and expression assays facilitated evaluation of candidate genes. An overrepresentation of genes involved in ovarian development and insulin-like signaling components within pollen foraging QTL regions suggests that an ancestral reproductive gene network was co-opted during the evolution of foraging specialization. The major QTL influencing defensive/aggressive behavior contains orthologs of genes involved in central nervous system activity and neurogenesis. Candidates at the other two defensive-behavior QTLs include modulators of sensory signaling (Am5HT 7 serotonin receptor, AmArr4 arrestin, and GABA-B-R1 receptor). These studies are the first step in linking natural variation in honeybee social behavior to the identification of underlying genes.

Original languageEnglish (US)
Pages (from-to)247-267
Number of pages21
JournalNaturwissenschaften
Volume94
Issue number4
DOIs
StatePublished - Apr 2007

Fingerprint

honeybee
Quantitative Trait Loci
Genomics
honey bees
quantitative trait loci
genomics
nest
Genes
nests
foraging
defensive behavior
gene
Bees
Apoidea
bee
genes
Social Behavior
bioinformatics
Pollen
Computational Biology

Keywords

  • Aggressive behavior
  • Apis mellifera
  • Behavior genetics
  • Candidate genes
  • Foraging behavior
  • Insulin-like signaling
  • Recombination rate

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Ecology

Cite this

Hunt, G. J., Amdam, G., Schlipalius, D., Emore, C., Sardesai, N., Williams, C. E., ... Page, R. (2007). Behavioral genomics of honeybee foraging and nest defense. Naturwissenschaften, 94(4), 247-267. https://doi.org/10.1007/s00114-006-0183-1

Behavioral genomics of honeybee foraging and nest defense. / Hunt, Greg J.; Amdam, Gro; Schlipalius, David; Emore, Christine; Sardesai, Nagesh; Williams, Christie E.; Rueppell, Olav; Guzmán-Novoa, Ernesto; Arechavaleta-Velasco, Miguel; Chandra, Sathees; Fondrk, M. Kim; Beye, Martin; Page, Robert.

In: Naturwissenschaften, Vol. 94, No. 4, 04.2007, p. 247-267.

Research output: Contribution to journalArticle

Hunt, GJ, Amdam, G, Schlipalius, D, Emore, C, Sardesai, N, Williams, CE, Rueppell, O, Guzmán-Novoa, E, Arechavaleta-Velasco, M, Chandra, S, Fondrk, MK, Beye, M & Page, R 2007, 'Behavioral genomics of honeybee foraging and nest defense', Naturwissenschaften, vol. 94, no. 4, pp. 247-267. https://doi.org/10.1007/s00114-006-0183-1
Hunt GJ, Amdam G, Schlipalius D, Emore C, Sardesai N, Williams CE et al. Behavioral genomics of honeybee foraging and nest defense. Naturwissenschaften. 2007 Apr;94(4):247-267. https://doi.org/10.1007/s00114-006-0183-1
Hunt, Greg J. ; Amdam, Gro ; Schlipalius, David ; Emore, Christine ; Sardesai, Nagesh ; Williams, Christie E. ; Rueppell, Olav ; Guzmán-Novoa, Ernesto ; Arechavaleta-Velasco, Miguel ; Chandra, Sathees ; Fondrk, M. Kim ; Beye, Martin ; Page, Robert. / Behavioral genomics of honeybee foraging and nest defense. In: Naturwissenschaften. 2007 ; Vol. 94, No. 4. pp. 247-267.
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