TY - JOUR
T1 - Behavioral effects of psychomotor stimulant infusions into amygdaloid nuclei
AU - O'Dell, Laura E.
AU - Sussman, Amy N.
AU - Meyer, Kym L.
AU - Neisewander, Janet
N1 - Funding Information:
The authors are grateful to Drs. Eddie Castañeda, Peter Killeen, and Stanley Parkinson for their comments on an earlier version of the manuscript. The authors also gratefully acknowledge the technical assistance of Dawn Charrier, Kathy Grote, Amanda Miller, and Brian Paul. This research was supported by the National Institute of Mental Health/Minority Neuroscience Training Program, the Howard Hughes Medical Institute through the Undergraduate Biological Science Education Program, and USPHS grant DA07730.
PY - 1999/6
Y1 - 1999/6
N2 - The role of amygdaloid nuclei in locomotion, stereotypy, and conditioned place preference (CPP) produced by psychomotor stimulants was examined. Five 2-day conditioning trials were conducted over 10 consecutive days. Rats received bilateral intracranial infusions of saline, cocaine (25-100 μg/side), or amphetamine (0.31-20 μg/side) into the ventricles (ICV), basolateral amygdala (BlA), or central amygdala (CeA) and were confined to a compartment. On alternating days, rats received sham infusions and were confined to a different compartment. Locomotion was measured daily, stereotypy was measured on trials 1 and 5, and CPP was measured 24 h after conditioning. ICV infusions of cocaine or amphetamine produced locomotion, rearing, and CPP. Intra-BlA and intra-CeA infusions of the highest dose of cocaine produced locomotion. In contrast, intra-CeA infusions of amphetamine potently produced locomotion and CPP. Intra-BlA infusions of amphetamine, however, did not produce any behavioral changes. These results suggest that the CeA, but not the BlA, is involved in initiating reward and locomotion produced by amphetamine. Copyright (C) 1999 American College of Neuropsychopharmacology.
AB - The role of amygdaloid nuclei in locomotion, stereotypy, and conditioned place preference (CPP) produced by psychomotor stimulants was examined. Five 2-day conditioning trials were conducted over 10 consecutive days. Rats received bilateral intracranial infusions of saline, cocaine (25-100 μg/side), or amphetamine (0.31-20 μg/side) into the ventricles (ICV), basolateral amygdala (BlA), or central amygdala (CeA) and were confined to a compartment. On alternating days, rats received sham infusions and were confined to a different compartment. Locomotion was measured daily, stereotypy was measured on trials 1 and 5, and CPP was measured 24 h after conditioning. ICV infusions of cocaine or amphetamine produced locomotion, rearing, and CPP. Intra-BlA and intra-CeA infusions of the highest dose of cocaine produced locomotion. In contrast, intra-CeA infusions of amphetamine potently produced locomotion and CPP. Intra-BlA infusions of amphetamine, however, did not produce any behavioral changes. These results suggest that the CeA, but not the BlA, is involved in initiating reward and locomotion produced by amphetamine. Copyright (C) 1999 American College of Neuropsychopharmacology.
KW - Amphetamine
KW - Cocaine
KW - Conditioned place preference
KW - Conditioning
KW - Drug-seeking behavior
KW - Locomotion
KW - Stereotypy
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U2 - 10.1016/S0893-133X(98)00083-9
DO - 10.1016/S0893-133X(98)00083-9
M3 - Article
C2 - 10327428
AN - SCOPUS:0033151378
SN - 0893-133X
VL - 20
SP - 591
EP - 602
JO - Neuropsychopharmacology
JF - Neuropsychopharmacology
IS - 6
ER -