Behavioral effects of psychomotor stimulant infusions into amygdaloid nuclei

Laura E. O'Dell, Amy N. Sussman, Kym L. Meyer, Janet Neisewander

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The role of amygdaloid nuclei in locomotion, stereotypy, and conditioned place preference (CPP) produced by psychomotor stimulants was examined. Five 2-day conditioning trials were conducted over 10 consecutive days. Rats received bilateral intracranial infusions of saline, cocaine (25-100 μg/side), or amphetamine (0.31-20 μg/side) into the ventricles (ICV), basolateral amygdala (BlA), or central amygdala (CeA) and were confined to a compartment. On alternating days, rats received sham infusions and were confined to a different compartment. Locomotion was measured daily, stereotypy was measured on trials 1 and 5, and CPP was measured 24 h after conditioning. ICV infusions of cocaine or amphetamine produced locomotion, rearing, and CPP. Intra-BlA and intra-CeA infusions of the highest dose of cocaine produced locomotion. In contrast, intra-CeA infusions of amphetamine potently produced locomotion and CPP. Intra-BlA infusions of amphetamine, however, did not produce any behavioral changes. These results suggest that the CeA, but not the BlA, is involved in initiating reward and locomotion produced by amphetamine. Copyright (C) 1999 American College of Neuropsychopharmacology.

Original languageEnglish (US)
Pages (from-to)591-602
Number of pages12
JournalNeuropsychopharmacology
Volume20
Issue number6
DOIs
StatePublished - Jun 1999

Fingerprint

Locomotion
Amygdala
Amphetamine
Cocaine
Reward
Basolateral Nuclear Complex
Central Amygdaloid Nucleus

Keywords

  • Amphetamine
  • Cocaine
  • Conditioned place preference
  • Conditioning
  • Drug-seeking behavior
  • Locomotion
  • Stereotypy

ASJC Scopus subject areas

  • Pharmacology

Cite this

Behavioral effects of psychomotor stimulant infusions into amygdaloid nuclei. / O'Dell, Laura E.; Sussman, Amy N.; Meyer, Kym L.; Neisewander, Janet.

In: Neuropsychopharmacology, Vol. 20, No. 6, 06.1999, p. 591-602.

Research output: Contribution to journalArticle

O'Dell, Laura E. ; Sussman, Amy N. ; Meyer, Kym L. ; Neisewander, Janet. / Behavioral effects of psychomotor stimulant infusions into amygdaloid nuclei. In: Neuropsychopharmacology. 1999 ; Vol. 20, No. 6. pp. 591-602.
@article{9b8b9542c45b412eba4df6388b9be3b9,
title = "Behavioral effects of psychomotor stimulant infusions into amygdaloid nuclei",
abstract = "The role of amygdaloid nuclei in locomotion, stereotypy, and conditioned place preference (CPP) produced by psychomotor stimulants was examined. Five 2-day conditioning trials were conducted over 10 consecutive days. Rats received bilateral intracranial infusions of saline, cocaine (25-100 μg/side), or amphetamine (0.31-20 μg/side) into the ventricles (ICV), basolateral amygdala (BlA), or central amygdala (CeA) and were confined to a compartment. On alternating days, rats received sham infusions and were confined to a different compartment. Locomotion was measured daily, stereotypy was measured on trials 1 and 5, and CPP was measured 24 h after conditioning. ICV infusions of cocaine or amphetamine produced locomotion, rearing, and CPP. Intra-BlA and intra-CeA infusions of the highest dose of cocaine produced locomotion. In contrast, intra-CeA infusions of amphetamine potently produced locomotion and CPP. Intra-BlA infusions of amphetamine, however, did not produce any behavioral changes. These results suggest that the CeA, but not the BlA, is involved in initiating reward and locomotion produced by amphetamine. Copyright (C) 1999 American College of Neuropsychopharmacology.",
keywords = "Amphetamine, Cocaine, Conditioned place preference, Conditioning, Drug-seeking behavior, Locomotion, Stereotypy",
author = "O'Dell, {Laura E.} and Sussman, {Amy N.} and Meyer, {Kym L.} and Janet Neisewander",
year = "1999",
month = "6",
doi = "10.1016/S0893-133X(98)00083-9",
language = "English (US)",
volume = "20",
pages = "591--602",
journal = "Neuropsychopharmacology",
issn = "0893-133X",
publisher = "Nature Publishing Group",
number = "6",

}

TY - JOUR

T1 - Behavioral effects of psychomotor stimulant infusions into amygdaloid nuclei

AU - O'Dell, Laura E.

AU - Sussman, Amy N.

AU - Meyer, Kym L.

AU - Neisewander, Janet

PY - 1999/6

Y1 - 1999/6

N2 - The role of amygdaloid nuclei in locomotion, stereotypy, and conditioned place preference (CPP) produced by psychomotor stimulants was examined. Five 2-day conditioning trials were conducted over 10 consecutive days. Rats received bilateral intracranial infusions of saline, cocaine (25-100 μg/side), or amphetamine (0.31-20 μg/side) into the ventricles (ICV), basolateral amygdala (BlA), or central amygdala (CeA) and were confined to a compartment. On alternating days, rats received sham infusions and were confined to a different compartment. Locomotion was measured daily, stereotypy was measured on trials 1 and 5, and CPP was measured 24 h after conditioning. ICV infusions of cocaine or amphetamine produced locomotion, rearing, and CPP. Intra-BlA and intra-CeA infusions of the highest dose of cocaine produced locomotion. In contrast, intra-CeA infusions of amphetamine potently produced locomotion and CPP. Intra-BlA infusions of amphetamine, however, did not produce any behavioral changes. These results suggest that the CeA, but not the BlA, is involved in initiating reward and locomotion produced by amphetamine. Copyright (C) 1999 American College of Neuropsychopharmacology.

AB - The role of amygdaloid nuclei in locomotion, stereotypy, and conditioned place preference (CPP) produced by psychomotor stimulants was examined. Five 2-day conditioning trials were conducted over 10 consecutive days. Rats received bilateral intracranial infusions of saline, cocaine (25-100 μg/side), or amphetamine (0.31-20 μg/side) into the ventricles (ICV), basolateral amygdala (BlA), or central amygdala (CeA) and were confined to a compartment. On alternating days, rats received sham infusions and were confined to a different compartment. Locomotion was measured daily, stereotypy was measured on trials 1 and 5, and CPP was measured 24 h after conditioning. ICV infusions of cocaine or amphetamine produced locomotion, rearing, and CPP. Intra-BlA and intra-CeA infusions of the highest dose of cocaine produced locomotion. In contrast, intra-CeA infusions of amphetamine potently produced locomotion and CPP. Intra-BlA infusions of amphetamine, however, did not produce any behavioral changes. These results suggest that the CeA, but not the BlA, is involved in initiating reward and locomotion produced by amphetamine. Copyright (C) 1999 American College of Neuropsychopharmacology.

KW - Amphetamine

KW - Cocaine

KW - Conditioned place preference

KW - Conditioning

KW - Drug-seeking behavior

KW - Locomotion

KW - Stereotypy

UR - http://www.scopus.com/inward/record.url?scp=0033151378&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033151378&partnerID=8YFLogxK

U2 - 10.1016/S0893-133X(98)00083-9

DO - 10.1016/S0893-133X(98)00083-9

M3 - Article

C2 - 10327428

AN - SCOPUS:0033151378

VL - 20

SP - 591

EP - 602

JO - Neuropsychopharmacology

JF - Neuropsychopharmacology

SN - 0893-133X

IS - 6

ER -