Behavioral effects of psychomotor stimulant infusions into amygdaloid nuclei

Laura E. O'Dell, Amy N. Sussman, Kym L. Meyer, Janet Neisewander

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

The role of amygdaloid nuclei in locomotion, stereotypy, and conditioned place preference (CPP) produced by psychomotor stimulants was examined. Five 2-day conditioning trials were conducted over 10 consecutive days. Rats received bilateral intracranial infusions of saline, cocaine (25-100 μg/side), or amphetamine (0.31-20 μg/side) into the ventricles (ICV), basolateral amygdala (BlA), or central amygdala (CeA) and were confined to a compartment. On alternating days, rats received sham infusions and were confined to a different compartment. Locomotion was measured daily, stereotypy was measured on trials 1 and 5, and CPP was measured 24 h after conditioning. ICV infusions of cocaine or amphetamine produced locomotion, rearing, and CPP. Intra-BlA and intra-CeA infusions of the highest dose of cocaine produced locomotion. In contrast, intra-CeA infusions of amphetamine potently produced locomotion and CPP. Intra-BlA infusions of amphetamine, however, did not produce any behavioral changes. These results suggest that the CeA, but not the BlA, is involved in initiating reward and locomotion produced by amphetamine. Copyright (C) 1999 American College of Neuropsychopharmacology.

Original languageEnglish (US)
Pages (from-to)591-602
Number of pages12
JournalNeuropsychopharmacology
Volume20
Issue number6
DOIs
StatePublished - Jun 1 1999

Keywords

  • Amphetamine
  • Cocaine
  • Conditioned place preference
  • Conditioning
  • Drug-seeking behavior
  • Locomotion
  • Stereotypy

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

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