Behavioral comparison of 4 and 6 month-old Ts65Dn mice

Age-related impairments in working and reference memory

Christopher L. Hunter, Heather Bimonte-Nelson, Ann Charlotte E Granholm

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Ts65Dn mice are partially trisomic for a segment of murine chromosome 16 similar to the gene segment on human chromosome 21 affected in Down's syndrome (DS). These animals display cognitive deficits, neurochemical imbalances, and cholinergic degeneration resembling alterations in DS and early onset Alzheimer's disease. The loss of basal forebrain cholinergic phenotype in Ts65Dn mice begins at approximately 6 months of age and may be due to an improperly functioning neurotrophic system. We compared 4 and 6 month-old Ts65Dn mice in a water-escape radial-arm maze task to investigate working and reference memory before and after the reported onset of cholinergic decline. Both 4 and 6 month-old Ts65Dn mice exhibited impaired performance compared to age-matched controls. However, the younger Ts65Dn mice displayed the capability to learn all working and reference memory measures, while the older Ts65Dn mice did not. Ts65Dn mice failed to maintain performance as working memory load increased, and the ability to handle an increasing working memory load also diminished with age. Collectively, these data suggest that major alterations in cognitive function occur in Ts65Dn mice between the ages of 4 and 6 months.

Original languageEnglish (US)
Pages (from-to)121-131
Number of pages11
JournalBehavioural Brain Research
Volume138
Issue number2
DOIs
StatePublished - Jan 22 2003
Externally publishedYes

Fingerprint

Short-Term Memory
Cholinergic Agents
Down Syndrome
Chromosomes, Human, Pair 16
Chromosomes, Human, Pair 21
Aptitude
Human Chromosomes
Cognition
Alzheimer Disease
Phenotype
Water
Genes

Keywords

  • Down's syndrome
  • Radial-arm maze
  • Reference memory
  • Ts65Dn
  • Working memory
  • Working memory load

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Behavioral comparison of 4 and 6 month-old Ts65Dn mice : Age-related impairments in working and reference memory. / Hunter, Christopher L.; Bimonte-Nelson, Heather; Granholm, Ann Charlotte E.

In: Behavioural Brain Research, Vol. 138, No. 2, 22.01.2003, p. 121-131.

Research output: Contribution to journalArticle

@article{39ddefed5d914e388f7d4bacff161220,
title = "Behavioral comparison of 4 and 6 month-old Ts65Dn mice: Age-related impairments in working and reference memory",
abstract = "Ts65Dn mice are partially trisomic for a segment of murine chromosome 16 similar to the gene segment on human chromosome 21 affected in Down's syndrome (DS). These animals display cognitive deficits, neurochemical imbalances, and cholinergic degeneration resembling alterations in DS and early onset Alzheimer's disease. The loss of basal forebrain cholinergic phenotype in Ts65Dn mice begins at approximately 6 months of age and may be due to an improperly functioning neurotrophic system. We compared 4 and 6 month-old Ts65Dn mice in a water-escape radial-arm maze task to investigate working and reference memory before and after the reported onset of cholinergic decline. Both 4 and 6 month-old Ts65Dn mice exhibited impaired performance compared to age-matched controls. However, the younger Ts65Dn mice displayed the capability to learn all working and reference memory measures, while the older Ts65Dn mice did not. Ts65Dn mice failed to maintain performance as working memory load increased, and the ability to handle an increasing working memory load also diminished with age. Collectively, these data suggest that major alterations in cognitive function occur in Ts65Dn mice between the ages of 4 and 6 months.",
keywords = "Down's syndrome, Radial-arm maze, Reference memory, Ts65Dn, Working memory, Working memory load",
author = "Hunter, {Christopher L.} and Heather Bimonte-Nelson and Granholm, {Ann Charlotte E}",
year = "2003",
month = "1",
day = "22",
doi = "10.1016/S0166-4328(02)00275-9",
language = "English (US)",
volume = "138",
pages = "121--131",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Behavioral comparison of 4 and 6 month-old Ts65Dn mice

T2 - Age-related impairments in working and reference memory

AU - Hunter, Christopher L.

AU - Bimonte-Nelson, Heather

AU - Granholm, Ann Charlotte E

PY - 2003/1/22

Y1 - 2003/1/22

N2 - Ts65Dn mice are partially trisomic for a segment of murine chromosome 16 similar to the gene segment on human chromosome 21 affected in Down's syndrome (DS). These animals display cognitive deficits, neurochemical imbalances, and cholinergic degeneration resembling alterations in DS and early onset Alzheimer's disease. The loss of basal forebrain cholinergic phenotype in Ts65Dn mice begins at approximately 6 months of age and may be due to an improperly functioning neurotrophic system. We compared 4 and 6 month-old Ts65Dn mice in a water-escape radial-arm maze task to investigate working and reference memory before and after the reported onset of cholinergic decline. Both 4 and 6 month-old Ts65Dn mice exhibited impaired performance compared to age-matched controls. However, the younger Ts65Dn mice displayed the capability to learn all working and reference memory measures, while the older Ts65Dn mice did not. Ts65Dn mice failed to maintain performance as working memory load increased, and the ability to handle an increasing working memory load also diminished with age. Collectively, these data suggest that major alterations in cognitive function occur in Ts65Dn mice between the ages of 4 and 6 months.

AB - Ts65Dn mice are partially trisomic for a segment of murine chromosome 16 similar to the gene segment on human chromosome 21 affected in Down's syndrome (DS). These animals display cognitive deficits, neurochemical imbalances, and cholinergic degeneration resembling alterations in DS and early onset Alzheimer's disease. The loss of basal forebrain cholinergic phenotype in Ts65Dn mice begins at approximately 6 months of age and may be due to an improperly functioning neurotrophic system. We compared 4 and 6 month-old Ts65Dn mice in a water-escape radial-arm maze task to investigate working and reference memory before and after the reported onset of cholinergic decline. Both 4 and 6 month-old Ts65Dn mice exhibited impaired performance compared to age-matched controls. However, the younger Ts65Dn mice displayed the capability to learn all working and reference memory measures, while the older Ts65Dn mice did not. Ts65Dn mice failed to maintain performance as working memory load increased, and the ability to handle an increasing working memory load also diminished with age. Collectively, these data suggest that major alterations in cognitive function occur in Ts65Dn mice between the ages of 4 and 6 months.

KW - Down's syndrome

KW - Radial-arm maze

KW - Reference memory

KW - Ts65Dn

KW - Working memory

KW - Working memory load

UR - http://www.scopus.com/inward/record.url?scp=0037460101&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037460101&partnerID=8YFLogxK

U2 - 10.1016/S0166-4328(02)00275-9

DO - 10.1016/S0166-4328(02)00275-9

M3 - Article

VL - 138

SP - 121

EP - 131

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

IS - 2

ER -