BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex

Jeffrey A. Kleim; Sheila Chan; Erin Pringle; Kellan Schallert; Vincent Procaccio; Richard Jimenez; Steven C. Cramer

doi:10.1038/nn1699

BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex

Jeffrey A. Kleim, Sheila Chan, Erin Pringle, Kellan Schallert, Vincent Procaccio, Richard Jimenez, Steven C. Cramer

Research output: Contribution to journal › Article › peer-review

454 Scopus citations

Abstract

Motor training can induce profound physiological plasticity within primary motor cortex, including changes in corticospinal output and motor map topography. Using transcranial magnetic stimulation, we show that training-dependent increases in the amplitude of motor-evoked potentials and motor map reorganization are reduced in healthy subjects with a val66met polymorphism in the brain-derived neurotrophic factor gene (BDNF), as compared to subjects without the polymorphism. The results suggest that BDNF is involved in mediating experience-dependent plasticity of human motor cortex.

Original language	English (US)
Pages (from-to)	735-737
Number of pages	3
Journal	Nature Neuroscience
Volume	9
Issue number	6
DOIs	https://doi.org/10.1038/nn1699
State	Published - Jun 16 2006
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience

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abstract = "Motor training can induce profound physiological plasticity within primary motor cortex, including changes in corticospinal output and motor map topography. Using transcranial magnetic stimulation, we show that training-dependent increases in the amplitude of motor-evoked potentials and motor map reorganization are reduced in healthy subjects with a val66met polymorphism in the brain-derived neurotrophic factor gene (BDNF), as compared to subjects without the polymorphism. The results suggest that BDNF is involved in mediating experience-dependent plasticity of human motor cortex.",

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AU - Schallert, Kellan

AU - Procaccio, Vincent

AU - Jimenez, Richard

AU - Cramer, Steven C.

PY - 2006/6/16

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AB - Motor training can induce profound physiological plasticity within primary motor cortex, including changes in corticospinal output and motor map topography. Using transcranial magnetic stimulation, we show that training-dependent increases in the amplitude of motor-evoked potentials and motor map reorganization are reduced in healthy subjects with a val66met polymorphism in the brain-derived neurotrophic factor gene (BDNF), as compared to subjects without the polymorphism. The results suggest that BDNF is involved in mediating experience-dependent plasticity of human motor cortex.

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BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex

Abstract

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