BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex

Jeffrey Kleim, Sheila Chan, Erin Pringle, Kellan Schallert, Vincent Procaccio, Richard Jimenez, Steven C. Cramer

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Abstract

Motor training can induce profound physiological plasticity within primary motor cortex, including changes in corticospinal output and motor map topography. Using transcranial magnetic stimulation, we show that training-dependent increases in the amplitude of motor-evoked potentials and motor map reorganization are reduced in healthy subjects with a val66met polymorphism in the brain-derived neurotrophic factor gene (BDNF), as compared to subjects without the polymorphism. The results suggest that BDNF is involved in mediating experience-dependent plasticity of human motor cortex.

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BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex. / Kleim, Jeffrey; Chan, Sheila; Pringle, Erin; Schallert, Kellan; Procaccio, Vincent; Jimenez, Richard; Cramer, Steven C.

In: Nature Neuroscience, Vol. 9, No. 6, 16.06.2006, p. 735-737.

Research output: Contribution to journalArticle