Abstract
Background: We earlier observed altered expression of p53 and Bcl-xL in oral cancer cell lines/tissues and wanted to evaluate these proteins for prediction of radiotherapy response and outcome. Methods: Thirty-nine paraffin-embedded, pretreatment oral cancer biopsies were analyzed for protein expression using immunohistochemistry and correlated with tumor response to radiotherapy and disease-free survival (DFS). Result: High p53 (p =.040) was observed in female versus male patients. Increased p53 intensity (p =.063) was observed in tobacco habitués (chewers ± smokers) versus patients with no habits. In univariate analysis, nodal positivity (p =.044) and favorable/complete tumor response (p =.002) exhibited a significant correlation with DFS, whereas tumor response emerged as an independent predictor of DFS in multivariate analysis. Significantly high Bcl-xL (p =.048) was observed in the unfavorable versus favorable responders. Conclusion: Our study suggests that Bcl-xL expression along with clinical parameters may be useful for identifying patients with oral cancer likely to draw maximum benefit from curative radiotherapy.
Original language | English (US) |
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Pages (from-to) | 1448-1453 |
Number of pages | 6 |
Journal | Head and Neck |
Volume | 35 |
Issue number | 10 |
DOIs | |
State | Published - Oct 2013 |
Externally published | Yes |
Keywords
- Bcl-xL
- Oral cancer
- p53
- radiotherapy
- tumor response
ASJC Scopus subject areas
- Otorhinolaryngology