Balancing selection and MHC

Philip W. Hedrick

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

The MHC is highly polymorphic in most vertebrates and the suggested selective mechanisms responsible for the maintenance of this variation are several, including maternal-fetal interaction, parasite resistance, and negative-assortative mating. Evidence for these mechanisms is reviewed and estimates of the amount of selection in a number of studies are given. Although there is much yet to be understood about the mechanism and extent of balancing selection at MHC, new advances in molecular genetic technology and increasing interest in MHC from many types of biologists promise answers in the near future.

Original languageEnglish (US)
Pages (from-to)207-214
Number of pages8
JournalGenetica
Volume104
Issue number3
StatePublished - 1998

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assortative mating
molecular genetics
biologists
Vertebrates
Molecular Biology
Parasites
parasite resistance
vertebrates
Maintenance
Mothers
Technology
parasites
vertebrate

Keywords

  • HLA
  • Maternal-fetal interaction
  • Negative-assortative mating
  • Parasite resistance
  • Polymorphism

ASJC Scopus subject areas

  • Genetics
  • Ecology, Evolution, Behavior and Systematics

Cite this

Hedrick, P. W. (1998). Balancing selection and MHC. Genetica, 104(3), 207-214.

Balancing selection and MHC. / Hedrick, Philip W.

In: Genetica, Vol. 104, No. 3, 1998, p. 207-214.

Research output: Contribution to journalArticle

Hedrick, PW 1998, 'Balancing selection and MHC', Genetica, vol. 104, no. 3, pp. 207-214.
Hedrick PW. Balancing selection and MHC. Genetica. 1998;104(3):207-214.
Hedrick, Philip W. / Balancing selection and MHC. In: Genetica. 1998 ; Vol. 104, No. 3. pp. 207-214.
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