Bacteremia associated with live attenuated χ8110 Salmonella enterica serovar typhi ISP1820 in healthy adult volunteers

Sharon E. Frey, Wendy Bollen, Donata Sizemore, Mark Campbell, Roy Curtiss

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Live attenuated χ8110 Salmonella enterica serovar Typhi ISP1820 vaccine was given in a dose-escalation trial to healthy, adult volunteers. Positive stool and blood cultures were noted, but limited, as were immune responses measured by ELISA and ELISPOT. Only volunteers with bacteremia developed immune responses; however, no symptoms were associated with bacteremia. The vaccine was insufficiently immunogenic for use as a vaccine. It is possible that reduced survival in the gut and reduced immunogenicity may have been due to the thawing of frozen inocula immediately prior to use.

Original languageEnglish (US)
Pages (from-to)32-37
Number of pages6
JournalClinical Immunology
Volume101
Issue number1
DOIs
StatePublished - 2001

Keywords

  • Antibody-secreting cells
  • Attenuated vaccines
  • Copro antibody
  • ELISA
  • ELISPOT
  • ISP1820
  • Oral vaccines
  • S. typhi 8110
  • Salmonella typhi
  • Serum antibody

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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