Back to Basics: Traditional Nottingham Grade Mitotic Counts Alone are Significant in Predicting Survival in Invasive Breast Carcinoma

James M. Chang, Ann E. McCullough, Amylou C. Dueck, Heidi E. Kosiorek, Idris T. Ocal, Thomas K. Lidner, Richard J. Gray, Nabil Wasif, Donald W. Northfelt, Karen Anderson, Barbara A. Pockaj

    Research output: Contribution to journalArticle

    6 Citations (Scopus)

    Abstract

    Background: Newer multigene molecular profiling assays for breast carcinoma rely heavily on the quantification of genes of proliferation, whereas traditional histological grading reports the mitotic count. The mitotic activity of invasive breast carcinomas may be undervalued; therefore, an evaluation of the prognostic significance of mitotic score in predicting prognosis was performed. Methods: Retrospective analysis of a single institutional cohort of newly diagnosed estrogen receptor positive (ER+), HER2 negative (HER2−) unilateral invasive breast carcinomas was performed. Mitotic scores from the 3-part Nottingham combined histological grade were compared with clinical parameters. Mitoses were counted on Olympus BX50 microscopes and assigned scores of 1–3 based on observed mitoses. Results: A total of 1292 ER+, HER2− invasive breast carcinoma patients were identified, with a median follow-up time of 2.6 years (range 0–14 years). Higher mitotic score was significantly associated with younger age, larger tumor size, angiolymphatic invasion, node-positive disease, higher stage, and the use of hormonal and cytotoxic chemotherapy. Mitotic score was significant in modeling time to local/regional recurrence (p = 0.02), recurrence-free survival/RFS (p 

    Original languageEnglish (US)
    Pages (from-to)509-515
    Number of pages7
    JournalAnnals of Surgical Oncology
    Volume22
    DOIs
    StatePublished - Dec 1 2015

    Fingerprint

    Breast Neoplasms
    Survival
    Mitosis
    Recurrence
    Estrogen Receptors
    Drug Therapy
    Genes
    Neoplasms

    ASJC Scopus subject areas

    • Surgery
    • Oncology

    Cite this

    Chang, J. M., McCullough, A. E., Dueck, A. C., Kosiorek, H. E., Ocal, I. T., Lidner, T. K., ... Pockaj, B. A. (2015). Back to Basics: Traditional Nottingham Grade Mitotic Counts Alone are Significant in Predicting Survival in Invasive Breast Carcinoma. Annals of Surgical Oncology, 22, 509-515. https://doi.org/10.1245/s10434-015-4616-y

    Back to Basics : Traditional Nottingham Grade Mitotic Counts Alone are Significant in Predicting Survival in Invasive Breast Carcinoma. / Chang, James M.; McCullough, Ann E.; Dueck, Amylou C.; Kosiorek, Heidi E.; Ocal, Idris T.; Lidner, Thomas K.; Gray, Richard J.; Wasif, Nabil; Northfelt, Donald W.; Anderson, Karen; Pockaj, Barbara A.

    In: Annals of Surgical Oncology, Vol. 22, 01.12.2015, p. 509-515.

    Research output: Contribution to journalArticle

    Chang, JM, McCullough, AE, Dueck, AC, Kosiorek, HE, Ocal, IT, Lidner, TK, Gray, RJ, Wasif, N, Northfelt, DW, Anderson, K & Pockaj, BA 2015, 'Back to Basics: Traditional Nottingham Grade Mitotic Counts Alone are Significant in Predicting Survival in Invasive Breast Carcinoma' Annals of Surgical Oncology, vol. 22, pp. 509-515. https://doi.org/10.1245/s10434-015-4616-y
    Chang, James M. ; McCullough, Ann E. ; Dueck, Amylou C. ; Kosiorek, Heidi E. ; Ocal, Idris T. ; Lidner, Thomas K. ; Gray, Richard J. ; Wasif, Nabil ; Northfelt, Donald W. ; Anderson, Karen ; Pockaj, Barbara A. / Back to Basics : Traditional Nottingham Grade Mitotic Counts Alone are Significant in Predicting Survival in Invasive Breast Carcinoma. In: Annals of Surgical Oncology. 2015 ; Vol. 22. pp. 509-515.
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