B7-H4, a Molecule of the B7 Family, Negatively Regulates T Cell Immunity

Gabriel L. Sica, In Hak Choi, Gefeng Zhu, Koji Tamada, Sheng Dian Wang, Hideto Tamura, Andrei Chapoval, Dallas B. Flies, Jürgen Bajorath, Lieping Chen

Research output: Contribution to journalArticle

473 Citations (Scopus)

Abstract

We identify a B7 family molecule, B7-H4, by protein sequence analysis and comparative molecular modeling. While B7-H4 mRNA is widely distributed in mouse and human peripheral tissues, cell surface expression of B7-H4 protein is limited and shows an inducible pattern on hematopoietic cells. Putative receptor of B7-H4 can be upregulated on activated T cells. By arresting cell cycle, B7-H4 ligation of T cells has a profound inhibitory effect on the growth, cytokine secretion, and development of cytotoxicity. Administration of B7-H4Ig into mice impairs antigen-specific T cell responses whereas blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 thus may participate in negative regulation of cell-mediated immunity in peripheral tissues.

Original languageEnglish (US)
Pages (from-to)849-861
Number of pages13
JournalImmunity
Volume18
Issue number6
DOIs
StatePublished - Jun 1 2003
Externally publishedYes

Fingerprint

B7 Antigens
Immunity
T-Lymphocytes
Protein Sequence Analysis
Cellular Immunity
Ligation
Cell Cycle
Monoclonal Antibodies
Cytokines
Antigens
Messenger RNA
Growth
Proteins

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Sica, G. L., Choi, I. H., Zhu, G., Tamada, K., Wang, S. D., Tamura, H., ... Chen, L. (2003). B7-H4, a Molecule of the B7 Family, Negatively Regulates T Cell Immunity. Immunity, 18(6), 849-861. https://doi.org/10.1016/S1074-7613(03)00152-3

B7-H4, a Molecule of the B7 Family, Negatively Regulates T Cell Immunity. / Sica, Gabriel L.; Choi, In Hak; Zhu, Gefeng; Tamada, Koji; Wang, Sheng Dian; Tamura, Hideto; Chapoval, Andrei; Flies, Dallas B.; Bajorath, Jürgen; Chen, Lieping.

In: Immunity, Vol. 18, No. 6, 01.06.2003, p. 849-861.

Research output: Contribution to journalArticle

Sica, GL, Choi, IH, Zhu, G, Tamada, K, Wang, SD, Tamura, H, Chapoval, A, Flies, DB, Bajorath, J & Chen, L 2003, 'B7-H4, a Molecule of the B7 Family, Negatively Regulates T Cell Immunity', Immunity, vol. 18, no. 6, pp. 849-861. https://doi.org/10.1016/S1074-7613(03)00152-3
Sica GL, Choi IH, Zhu G, Tamada K, Wang SD, Tamura H et al. B7-H4, a Molecule of the B7 Family, Negatively Regulates T Cell Immunity. Immunity. 2003 Jun 1;18(6):849-861. https://doi.org/10.1016/S1074-7613(03)00152-3
Sica, Gabriel L. ; Choi, In Hak ; Zhu, Gefeng ; Tamada, Koji ; Wang, Sheng Dian ; Tamura, Hideto ; Chapoval, Andrei ; Flies, Dallas B. ; Bajorath, Jürgen ; Chen, Lieping. / B7-H4, a Molecule of the B7 Family, Negatively Regulates T Cell Immunity. In: Immunity. 2003 ; Vol. 18, No. 6. pp. 849-861.
@article{645f7ba8eaf849a98168eac6a2448476,
title = "B7-H4, a Molecule of the B7 Family, Negatively Regulates T Cell Immunity",
abstract = "We identify a B7 family molecule, B7-H4, by protein sequence analysis and comparative molecular modeling. While B7-H4 mRNA is widely distributed in mouse and human peripheral tissues, cell surface expression of B7-H4 protein is limited and shows an inducible pattern on hematopoietic cells. Putative receptor of B7-H4 can be upregulated on activated T cells. By arresting cell cycle, B7-H4 ligation of T cells has a profound inhibitory effect on the growth, cytokine secretion, and development of cytotoxicity. Administration of B7-H4Ig into mice impairs antigen-specific T cell responses whereas blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 thus may participate in negative regulation of cell-mediated immunity in peripheral tissues.",
author = "Sica, {Gabriel L.} and Choi, {In Hak} and Gefeng Zhu and Koji Tamada and Wang, {Sheng Dian} and Hideto Tamura and Andrei Chapoval and Flies, {Dallas B.} and J{\"u}rgen Bajorath and Lieping Chen",
year = "2003",
month = "6",
day = "1",
doi = "10.1016/S1074-7613(03)00152-3",
language = "English (US)",
volume = "18",
pages = "849--861",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "6",

}

TY - JOUR

T1 - B7-H4, a Molecule of the B7 Family, Negatively Regulates T Cell Immunity

AU - Sica, Gabriel L.

AU - Choi, In Hak

AU - Zhu, Gefeng

AU - Tamada, Koji

AU - Wang, Sheng Dian

AU - Tamura, Hideto

AU - Chapoval, Andrei

AU - Flies, Dallas B.

AU - Bajorath, Jürgen

AU - Chen, Lieping

PY - 2003/6/1

Y1 - 2003/6/1

N2 - We identify a B7 family molecule, B7-H4, by protein sequence analysis and comparative molecular modeling. While B7-H4 mRNA is widely distributed in mouse and human peripheral tissues, cell surface expression of B7-H4 protein is limited and shows an inducible pattern on hematopoietic cells. Putative receptor of B7-H4 can be upregulated on activated T cells. By arresting cell cycle, B7-H4 ligation of T cells has a profound inhibitory effect on the growth, cytokine secretion, and development of cytotoxicity. Administration of B7-H4Ig into mice impairs antigen-specific T cell responses whereas blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 thus may participate in negative regulation of cell-mediated immunity in peripheral tissues.

AB - We identify a B7 family molecule, B7-H4, by protein sequence analysis and comparative molecular modeling. While B7-H4 mRNA is widely distributed in mouse and human peripheral tissues, cell surface expression of B7-H4 protein is limited and shows an inducible pattern on hematopoietic cells. Putative receptor of B7-H4 can be upregulated on activated T cells. By arresting cell cycle, B7-H4 ligation of T cells has a profound inhibitory effect on the growth, cytokine secretion, and development of cytotoxicity. Administration of B7-H4Ig into mice impairs antigen-specific T cell responses whereas blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 thus may participate in negative regulation of cell-mediated immunity in peripheral tissues.

UR - http://www.scopus.com/inward/record.url?scp=0038094524&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038094524&partnerID=8YFLogxK

U2 - 10.1016/S1074-7613(03)00152-3

DO - 10.1016/S1074-7613(03)00152-3

M3 - Article

C2 - 12818165

AN - SCOPUS:0038094524

VL - 18

SP - 849

EP - 861

JO - Immunity

JF - Immunity

SN - 1074-7613

IS - 6

ER -