Abstract
B7-H3 is a B7 family molecule with T cell costimulatory function in vitro. The in vivo role of B7-H3 in the stimulation of tumor immunity is unclear. We report here that expression of B7-H3 by transfection of the mouse P815 tumor line enhances its immunogenicity, leading to the regression of tumors and amplification of a tumor-specific CD8+ CTL response in syngeneic mice. Tumor cells engineered to express B7-H3 elicit a rapid clonal expansion of P1A tumor Ag-specific CD8+ CTL in lymphoid organs in vivo and acquire the ability to directly stimulate T cell growth, division, and development of cytolytic activity in vitro. Our results thus establish a role for B7-H3 in the costimulation of T cell immune responses in vivo.
Original language | English (US) |
---|---|
Pages (from-to) | 5445-5450 |
Number of pages | 6 |
Journal | Journal of Immunology |
Volume | 173 |
Issue number | 9 |
DOIs | |
State | Published - Nov 1 2004 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology