B-cell infiltration in the respiratory mucosa of Turkeys exposed to subtype C avian metapneumovirus

Mi Cha Ra, Mahesh Khatri, Jagdev M. Sharma

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Turkeys exposed to avian metapneumovirus (aMPV) subtype C showed extensive lymphoid cell infiltrations in the nasal turbinates of the upper respiratory tract. The cellular infiltration occurred after the first virus exposure but not after reexposure. Quantitation of the relative proportions of mucosal immunoglobulin (Ig)A+, IgG+, and IgM+ cells in controls and virus-exposed turkeys revealed that at 7 days after the first virus exposure, when mucosal infiltration was well pronounced, there was a significant increase (P < 0.05) in the numbers of infiltrating IgA+ but not of IgG+ and IgM+ cells. After the second virus exposure, although the overall numbers of mucosal lymphoid cells were similar in the virus-exposed and control turkeys, the relative proportions of IgA+ and IgG+ cells were significantly higher in the virus-exposed turkeys (P < 0.05) than in controls. Furthermore, elevated levels of aMPV-specific IgA were detected in the nasal secretions and the bile of virus-exposed birds after the second but not after the first virus exposure. These results suggest, for the first time, the possible involvement of local mucosal immunoglobulins in the pathogenesis of aMPV in turkeys.

Original languageEnglish (US)
Pages (from-to)764-770
Number of pages7
JournalAvian Diseases
Volume51
Issue number3
DOIs
StatePublished - Sep 2007
Externally publishedYes

Fingerprint

Metapneumovirus
Avian metapneumovirus
respiratory mucosa
Respiratory Mucosa
B-lymphocytes
B-Lymphocytes
Viruses
viruses
Immunoglobulin A
Immunoglobulin G
Nose
Immunoglobulin M
cells
Lymphocytes
immunoglobulin A
Turbinates
bile
respiratory system
Bile
Respiratory System

Keywords

  • Avian metapneumovirus
  • B cells
  • IgA
  • Mucosal immunity
  • Turkeys
  • Upper respiratory tract

ASJC Scopus subject areas

  • Immunology
  • Cancer Research
  • veterinary(all)

Cite this

B-cell infiltration in the respiratory mucosa of Turkeys exposed to subtype C avian metapneumovirus. / Ra, Mi Cha; Khatri, Mahesh; Sharma, Jagdev M.

In: Avian Diseases, Vol. 51, No. 3, 09.2007, p. 764-770.

Research output: Contribution to journalArticle

Ra, Mi Cha ; Khatri, Mahesh ; Sharma, Jagdev M. / B-cell infiltration in the respiratory mucosa of Turkeys exposed to subtype C avian metapneumovirus. In: Avian Diseases. 2007 ; Vol. 51, No. 3. pp. 764-770.
@article{1b9ad18ad99a4e388a9001399d899806,
title = "B-cell infiltration in the respiratory mucosa of Turkeys exposed to subtype C avian metapneumovirus",
abstract = "Turkeys exposed to avian metapneumovirus (aMPV) subtype C showed extensive lymphoid cell infiltrations in the nasal turbinates of the upper respiratory tract. The cellular infiltration occurred after the first virus exposure but not after reexposure. Quantitation of the relative proportions of mucosal immunoglobulin (Ig)A+, IgG+, and IgM+ cells in controls and virus-exposed turkeys revealed that at 7 days after the first virus exposure, when mucosal infiltration was well pronounced, there was a significant increase (P < 0.05) in the numbers of infiltrating IgA+ but not of IgG+ and IgM+ cells. After the second virus exposure, although the overall numbers of mucosal lymphoid cells were similar in the virus-exposed and control turkeys, the relative proportions of IgA+ and IgG+ cells were significantly higher in the virus-exposed turkeys (P < 0.05) than in controls. Furthermore, elevated levels of aMPV-specific IgA were detected in the nasal secretions and the bile of virus-exposed birds after the second but not after the first virus exposure. These results suggest, for the first time, the possible involvement of local mucosal immunoglobulins in the pathogenesis of aMPV in turkeys.",
keywords = "Avian metapneumovirus, B cells, IgA, Mucosal immunity, Turkeys, Upper respiratory tract",
author = "Ra, {Mi Cha} and Mahesh Khatri and Sharma, {Jagdev M.}",
year = "2007",
month = "9",
doi = "10.1637/0005-2086(2007)51[764:BIITRM]2.0.CO;2",
language = "English (US)",
volume = "51",
pages = "764--770",
journal = "Avian Diseases",
issn = "0005-2086",
publisher = "American Association of Avian Pathologists",
number = "3",

}

TY - JOUR

T1 - B-cell infiltration in the respiratory mucosa of Turkeys exposed to subtype C avian metapneumovirus

AU - Ra, Mi Cha

AU - Khatri, Mahesh

AU - Sharma, Jagdev M.

PY - 2007/9

Y1 - 2007/9

N2 - Turkeys exposed to avian metapneumovirus (aMPV) subtype C showed extensive lymphoid cell infiltrations in the nasal turbinates of the upper respiratory tract. The cellular infiltration occurred after the first virus exposure but not after reexposure. Quantitation of the relative proportions of mucosal immunoglobulin (Ig)A+, IgG+, and IgM+ cells in controls and virus-exposed turkeys revealed that at 7 days after the first virus exposure, when mucosal infiltration was well pronounced, there was a significant increase (P < 0.05) in the numbers of infiltrating IgA+ but not of IgG+ and IgM+ cells. After the second virus exposure, although the overall numbers of mucosal lymphoid cells were similar in the virus-exposed and control turkeys, the relative proportions of IgA+ and IgG+ cells were significantly higher in the virus-exposed turkeys (P < 0.05) than in controls. Furthermore, elevated levels of aMPV-specific IgA were detected in the nasal secretions and the bile of virus-exposed birds after the second but not after the first virus exposure. These results suggest, for the first time, the possible involvement of local mucosal immunoglobulins in the pathogenesis of aMPV in turkeys.

AB - Turkeys exposed to avian metapneumovirus (aMPV) subtype C showed extensive lymphoid cell infiltrations in the nasal turbinates of the upper respiratory tract. The cellular infiltration occurred after the first virus exposure but not after reexposure. Quantitation of the relative proportions of mucosal immunoglobulin (Ig)A+, IgG+, and IgM+ cells in controls and virus-exposed turkeys revealed that at 7 days after the first virus exposure, when mucosal infiltration was well pronounced, there was a significant increase (P < 0.05) in the numbers of infiltrating IgA+ but not of IgG+ and IgM+ cells. After the second virus exposure, although the overall numbers of mucosal lymphoid cells were similar in the virus-exposed and control turkeys, the relative proportions of IgA+ and IgG+ cells were significantly higher in the virus-exposed turkeys (P < 0.05) than in controls. Furthermore, elevated levels of aMPV-specific IgA were detected in the nasal secretions and the bile of virus-exposed birds after the second but not after the first virus exposure. These results suggest, for the first time, the possible involvement of local mucosal immunoglobulins in the pathogenesis of aMPV in turkeys.

KW - Avian metapneumovirus

KW - B cells

KW - IgA

KW - Mucosal immunity

KW - Turkeys

KW - Upper respiratory tract

UR - http://www.scopus.com/inward/record.url?scp=34748867875&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34748867875&partnerID=8YFLogxK

U2 - 10.1637/0005-2086(2007)51[764:BIITRM]2.0.CO;2

DO - 10.1637/0005-2086(2007)51[764:BIITRM]2.0.CO;2

M3 - Article

VL - 51

SP - 764

EP - 770

JO - Avian Diseases

JF - Avian Diseases

SN - 0005-2086

IS - 3

ER -