Autoimmune hepatitis: A review

Andrea A. Gossard, Keith Lindor

Research output: Contribution to journalReview article

31 Scopus citations

Abstract

Autoimmune hepatitis (AIH) is an inflammatory liver disease that predominantly affects females. The disease is characterized histologically by interface hepatitis, biochemically by increased aspartate and alanine aminotransferase levels, and serologically by the presence of autoantibodies and elevated levels of immunoglobulin G. AIH affects both adults and children, and is particularly aggressive in the latter group. It is a relatively rare but devastating disease, which progresses rapidly unless immunosuppressive treatment is started promptly. Treatment is often successful at inducing remission of disease, and this can lead to a normal life expectancy. However, progression to cirrhosis can and does occur in some. For those with advanced-stage disease and complications, consideration of liver transplantation is appropriate.

Original languageEnglish (US)
Pages (from-to)498-503
Number of pages6
JournalJournal of Gastroenterology
Volume47
Issue number5
DOIs
StatePublished - May 1 2012

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Keywords

  • Autoimmune disease
  • Autoimmune hepatitis
  • Autoimmune liver disease
  • Liver disease

ASJC Scopus subject areas

  • Gastroenterology

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