Autoantibody Profiling for Cancer Detection

Ji Qiu, Sam Hanash

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Despite substantial progress in the understanding of the pathogenesis of cancer, the development and implementation of strategies for early cancer detection have lagged behind. Harnessing the immune response to tumor antigens is particularly useful for early detection because the immune response occurs early during tumor development and affords signal amplification with the end product, namely reactive immunoglobulins, being released into the circulation allowing easy access through the blood. This article presents recent developments in autoantibody profiling with a focus on proteomic approaches and applications to lung cancer.

Original languageEnglish (US)
Pages (from-to)31-46
Number of pages16
JournalClinics in Laboratory Medicine
Volume29
Issue number1
DOIs
StatePublished - Mar 2009
Externally publishedYes

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Neoplasm Antigens
Autoantibodies
Amplification
Immunoglobulins
Tumors
Blood
Early Detection of Cancer
Proteomics
Lung Neoplasms
Neoplasms

Keywords

  • Antibody
  • Cancer detection
  • Protein microarray
  • Proteomics
  • Tumor antigen

ASJC Scopus subject areas

  • Biochemistry, medical
  • Clinical Biochemistry

Cite this

Autoantibody Profiling for Cancer Detection. / Qiu, Ji; Hanash, Sam.

In: Clinics in Laboratory Medicine, Vol. 29, No. 1, 03.2009, p. 31-46.

Research output: Contribution to journalArticle

Qiu, Ji ; Hanash, Sam. / Autoantibody Profiling for Cancer Detection. In: Clinics in Laboratory Medicine. 2009 ; Vol. 29, No. 1. pp. 31-46.
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