Autoantibodies to oxidized LDL and cardiovascular risk: The Framingham Offspring Study

Peter W.F. Wilson; Ori Ben-Yehuda; Judy McNamara; Joseph Massaro; Joseph Witztum; Peter D. Reaven

doi:10.1016/j.atherosclerosis.2005.12.013

Autoantibodies to oxidized LDL and cardiovascular risk: The Framingham Offspring Study

Peter W.F. Wilson, Ori Ben-Yehuda, Judy McNamara, Joseph Massaro, Joseph Witztum, Peter D. Reaven

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Background: The relation between measures of oxidation of lipid particles and cardiovascular disease has not been extensively investigated prospectively on a population basis. Methods: A community cohort of 1192 men and 1427 women with measures of IgG antibodies to oxidized LDL were followed 8 years for the development of initial coronary heart disease (CHD) and cardiovascular disease (CVD) events. Results: Levels of IgG autoantibodies to a form of oxidized LDL were significantly associated with age in both sexes, positively with fibrinogen in men and negatively with HDL cholesterol in women. In sex-specific models that adjusted for age alone or those that adjusted for age, cholesterol, HDL cholesterol, smoking, and diabetes mellitus, there was no relation between level of antibodies to oxidized LDL and the development of CHD or CVD. Conclusion: Autoantibodies to oxidized LDL were strongly related to age and were not related to incident CHD or CVD over 8 years of follow up.

Original language	English (US)
Pages (from-to)	364-368
Number of pages	5
Journal	Atherosclerosis
Volume	189
Issue number	2
DOIs	https://doi.org/10.1016/j.atherosclerosis.2005.12.013
State	Published - Dec 2006
Externally published	Yes

Keywords

Atherosclerosis
Autoantibodies
Cardiovascular disease
Epidemiology
Oxidation
Risk factors

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.atherosclerosis.2005.12.013

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title = "Autoantibodies to oxidized LDL and cardiovascular risk: The Framingham Offspring Study",

abstract = "Background: The relation between measures of oxidation of lipid particles and cardiovascular disease has not been extensively investigated prospectively on a population basis. Methods: A community cohort of 1192 men and 1427 women with measures of IgG antibodies to oxidized LDL were followed 8 years for the development of initial coronary heart disease (CHD) and cardiovascular disease (CVD) events. Results: Levels of IgG autoantibodies to a form of oxidized LDL were significantly associated with age in both sexes, positively with fibrinogen in men and negatively with HDL cholesterol in women. In sex-specific models that adjusted for age alone or those that adjusted for age, cholesterol, HDL cholesterol, smoking, and diabetes mellitus, there was no relation between level of antibodies to oxidized LDL and the development of CHD or CVD. Conclusion: Autoantibodies to oxidized LDL were strongly related to age and were not related to incident CHD or CVD over 8 years of follow up.",

keywords = "Atherosclerosis, Autoantibodies, Cardiovascular disease, Epidemiology, Oxidation, Risk factors",

author = "Wilson, {Peter W.F.} and Ori Ben-Yehuda and Judy McNamara and Joseph Massaro and Joseph Witztum and Reaven, {Peter D.}",

year = "2006",

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doi = "10.1016/j.atherosclerosis.2005.12.013",

language = "English (US)",

volume = "189",

pages = "364--368",

journal = "Atherosclerosis",

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T1 - Autoantibodies to oxidized LDL and cardiovascular risk

T2 - The Framingham Offspring Study

AU - Wilson, Peter W.F.

AU - Ben-Yehuda, Ori

AU - McNamara, Judy

AU - Massaro, Joseph

AU - Witztum, Joseph

AU - Reaven, Peter D.

PY - 2006/12

Y1 - 2006/12

N2 - Background: The relation between measures of oxidation of lipid particles and cardiovascular disease has not been extensively investigated prospectively on a population basis. Methods: A community cohort of 1192 men and 1427 women with measures of IgG antibodies to oxidized LDL were followed 8 years for the development of initial coronary heart disease (CHD) and cardiovascular disease (CVD) events. Results: Levels of IgG autoantibodies to a form of oxidized LDL were significantly associated with age in both sexes, positively with fibrinogen in men and negatively with HDL cholesterol in women. In sex-specific models that adjusted for age alone or those that adjusted for age, cholesterol, HDL cholesterol, smoking, and diabetes mellitus, there was no relation between level of antibodies to oxidized LDL and the development of CHD or CVD. Conclusion: Autoantibodies to oxidized LDL were strongly related to age and were not related to incident CHD or CVD over 8 years of follow up.

AB - Background: The relation between measures of oxidation of lipid particles and cardiovascular disease has not been extensively investigated prospectively on a population basis. Methods: A community cohort of 1192 men and 1427 women with measures of IgG antibodies to oxidized LDL were followed 8 years for the development of initial coronary heart disease (CHD) and cardiovascular disease (CVD) events. Results: Levels of IgG autoantibodies to a form of oxidized LDL were significantly associated with age in both sexes, positively with fibrinogen in men and negatively with HDL cholesterol in women. In sex-specific models that adjusted for age alone or those that adjusted for age, cholesterol, HDL cholesterol, smoking, and diabetes mellitus, there was no relation between level of antibodies to oxidized LDL and the development of CHD or CVD. Conclusion: Autoantibodies to oxidized LDL were strongly related to age and were not related to incident CHD or CVD over 8 years of follow up.

KW - Atherosclerosis

KW - Autoantibodies

KW - Cardiovascular disease

KW - Epidemiology

KW - Oxidation

KW - Risk factors

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Autoantibodies to oxidized LDL and cardiovascular risk: The Framingham Offspring Study

Abstract

Keywords

ASJC Scopus subject areas

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