Abstract
This paper reports development of three dimensional (3-D) silicon microstructures and the utilization of these microenvironments to study the behavior and response of human breast cancer cells separately and in co-culture with human fibroblast cells. The proposed devices consist of arrays of isotropic microchambers interconnected with channels fabricated using a single-mask, single-isotropic-etch process. Cancer cells formed stable adhesions with the curved sidewalls and their localization were dependent on the depth of microchambers. The dependence of the cancer cells' localization on geometrical parameters was not significant in co-culture compared to separate culture.
| Original language | English (US) |
|---|---|
| Title of host publication | 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences - The Proceedings of MicroTAS 2008 Conference |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 1819-1821 |
| Number of pages | 3 |
| State | Published - 2008 |
| Externally published | Yes |
| Event | 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008 - San Diego, CA, United States Duration: Oct 12 2008 → Oct 16 2008 |
Other
| Other | 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008 |
|---|---|
| Country/Territory | United States |
| City | San Diego, CA |
| Period | 10/12/08 → 10/16/08 |
Keywords
- Breast cancer
- Cellular behavior
- Isotropic microchambers
- MEMS
ASJC Scopus subject areas
- Chemical Engineering (miscellaneous)
- Bioengineering