Attachment and growth behavior of metastatic breast cancer cells in MEMS-based silicon microenvironmenTS

Mehdi Nikkhah, J. S. Strobl, A. Omotosho, M. Agah

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper reports development of three dimensional (3-D) silicon microstructures and the utilization of these microenvironments to study the behavior and response of human breast cancer cells separately and in co-culture with human fibroblast cells. The proposed devices consist of arrays of isotropic microchambers interconnected with channels fabricated using a single-mask, single-isotropic-etch process. Cancer cells formed stable adhesions with the curved sidewalls and their localization were dependent on the depth of microchambers. The dependence of the cancer cells' localization on geometrical parameters was not significant in co-culture compared to separate culture.

Original languageEnglish (US)
Title of host publication12th International Conference on Miniaturized Systems for Chemistry and Life Sciences - The Proceedings of MicroTAS 2008 Conference
PublisherChemical and Biological Microsystems Society
Pages1819-1821
Number of pages3
StatePublished - 2008
Externally publishedYes
Event12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008 - San Diego, CA, United States
Duration: Oct 12 2008Oct 16 2008

Other

Other12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008
CountryUnited States
CitySan Diego, CA
Period10/12/0810/16/08

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Keywords

  • Breast cancer
  • Cellular behavior
  • Isotropic microchambers
  • MEMS

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

Cite this

Nikkhah, M., Strobl, J. S., Omotosho, A., & Agah, M. (2008). Attachment and growth behavior of metastatic breast cancer cells in MEMS-based silicon microenvironmenTS. In 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences - The Proceedings of MicroTAS 2008 Conference (pp. 1819-1821). Chemical and Biological Microsystems Society.