Atoms to Phenotypes: Molecular Design Principles of Cellular Energy Metabolism

Abhishek Singharoy, Christopher Maffeo, Karelia H. Delgado-Magnero, David J.K. Swainsbury, Melih Sener, Ulrich Kleinekathöfer, John W. Vant, Jonathan Nguyen, Andrew Hitchcock, Barry Isralewitz, Ivan Teo, Danielle E. Chandler, John E. Stone, James C. Phillips, Taras V. Pogorelov, M. Ilaria Mallus, Christophe Chipot, Zaida Luthey-Schulten, D. Peter Tieleman, C. Neil HunterEmad Tajkhorshid, Aleksei Aksimentiev, Klaus Schulten

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

A full atomic resolution model of an entire organelle, the photosynthetic chromatophore vesicle of a purple bacterium, is constructed and reveals how the photosynthetic apparatus is optimized for ATP production in low-light habitats.

Original languageEnglish (US)
Pages (from-to)1098-1111.e23
JournalCell
Volume179
Issue number5
DOIs
StatePublished - Nov 14 2019

Keywords

  • MD
  • bioenergetics
  • biological membranes
  • charge transport
  • chromatophore
  • integrative model
  • mitochondria
  • molecular dynamics simulation
  • optical spectroscopy
  • photosynthesis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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