Asthma and bronchial hyperresponsiveness linked to the XY long arm pseudoautosomal region

Kenneth J. Holroyd, Laura C. Martinati, Elisabetta Trabetti, Titia Scherpbier, Scott M. Eleff, Attilio L. Boner, Pier Franco Pignatti, Matthew B. Kiser, Carl R. Dragwa, Frank Hubbard, Christine D. Sullivan, Luigi Grasso, Carol J. Messler, Minxue Huang, Ying Hu, Nicholas C. Nicolaides, Kenneth H. Buetow, Roy C. Levitt

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

We examined the long arm XY pseudoautosomal region for linkage to asthma, serum IgE, and bronchial hyperresponsiveness. In 57 Caucasian families multipoint nonparametric analyses provide evidence for linkage between DXYS154 and bronchial hyperresponsiveness (P = 0.000057) or asthma (P = 0.00065). This genomic region is approximately 320 kb in size and contains the interleukin-9 receptor gene. These results suggest that a gene controlling asthma and bronchial hyperresponsiveness maybe located in this region and that the interleukin-9 receptor is a potential candidate.

Original languageEnglish (US)
Pages (from-to)233-235
Number of pages3
JournalGenomics
Volume52
Issue number2
DOIs
StatePublished - Sep 1 1998
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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    Holroyd, K. J., Martinati, L. C., Trabetti, E., Scherpbier, T., Eleff, S. M., Boner, A. L., Pignatti, P. F., Kiser, M. B., Dragwa, C. R., Hubbard, F., Sullivan, C. D., Grasso, L., Messler, C. J., Huang, M., Hu, Y., Nicolaides, N. C., Buetow, K. H., & Levitt, R. C. (1998). Asthma and bronchial hyperresponsiveness linked to the XY long arm pseudoautosomal region. Genomics, 52(2), 233-235. https://doi.org/10.1006/geno.1998.5445