Asthma and bronchial hyperresponsiveness linked to the XY long arm pseudoautosomal region

Kenneth J. Holroyd, Laura C. Martinati, Elisabetta Trabetti, Titia Scherpbier, Scott M. Eleff, Attilio L. Boner, Pier Franco Pignatti, Matthew B. Kiser, Carl R. Dragwa, Frank Hubbard, Christine D. Sullivan, Luigi Grasso, Carol J. Messler, Minxue Huang, Ying Hu, Nicholas C. Nicolaides, Kenneth Buetow, Roy C. Levitt

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

We examined the long arm XY pseudoautosomal region for linkage to asthma, serum IgE, and bronchial hyperresponsiveness. In 57 Caucasian families multipoint nonparametric analyses provide evidence for linkage between DXYS154 and bronchial hyperresponsiveness (P = 0.000057) or asthma (P = 0.00065). This genomic region is approximately 320 kb in size and contains the interleukin-9 receptor gene. These results suggest that a gene controlling asthma and bronchial hyperresponsiveness maybe located in this region and that the interleukin-9 receptor is a potential candidate.

Original languageEnglish (US)
Pages (from-to)233-235
Number of pages3
JournalGenomics
Volume52
Issue number2
DOIs
StatePublished - Sep 1 1998
Externally publishedYes

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Interleukin-9 Receptors
Asthma
Immunoglobulin E
Genes
Serum
Pseudoautosomal Regions

ASJC Scopus subject areas

  • Genetics

Cite this

Holroyd, K. J., Martinati, L. C., Trabetti, E., Scherpbier, T., Eleff, S. M., Boner, A. L., ... Levitt, R. C. (1998). Asthma and bronchial hyperresponsiveness linked to the XY long arm pseudoautosomal region. Genomics, 52(2), 233-235. https://doi.org/10.1006/geno.1998.5445

Asthma and bronchial hyperresponsiveness linked to the XY long arm pseudoautosomal region. / Holroyd, Kenneth J.; Martinati, Laura C.; Trabetti, Elisabetta; Scherpbier, Titia; Eleff, Scott M.; Boner, Attilio L.; Pignatti, Pier Franco; Kiser, Matthew B.; Dragwa, Carl R.; Hubbard, Frank; Sullivan, Christine D.; Grasso, Luigi; Messler, Carol J.; Huang, Minxue; Hu, Ying; Nicolaides, Nicholas C.; Buetow, Kenneth; Levitt, Roy C.

In: Genomics, Vol. 52, No. 2, 01.09.1998, p. 233-235.

Research output: Contribution to journalArticle

Holroyd, KJ, Martinati, LC, Trabetti, E, Scherpbier, T, Eleff, SM, Boner, AL, Pignatti, PF, Kiser, MB, Dragwa, CR, Hubbard, F, Sullivan, CD, Grasso, L, Messler, CJ, Huang, M, Hu, Y, Nicolaides, NC, Buetow, K & Levitt, RC 1998, 'Asthma and bronchial hyperresponsiveness linked to the XY long arm pseudoautosomal region', Genomics, vol. 52, no. 2, pp. 233-235. https://doi.org/10.1006/geno.1998.5445
Holroyd KJ, Martinati LC, Trabetti E, Scherpbier T, Eleff SM, Boner AL et al. Asthma and bronchial hyperresponsiveness linked to the XY long arm pseudoautosomal region. Genomics. 1998 Sep 1;52(2):233-235. https://doi.org/10.1006/geno.1998.5445
Holroyd, Kenneth J. ; Martinati, Laura C. ; Trabetti, Elisabetta ; Scherpbier, Titia ; Eleff, Scott M. ; Boner, Attilio L. ; Pignatti, Pier Franco ; Kiser, Matthew B. ; Dragwa, Carl R. ; Hubbard, Frank ; Sullivan, Christine D. ; Grasso, Luigi ; Messler, Carol J. ; Huang, Minxue ; Hu, Ying ; Nicolaides, Nicholas C. ; Buetow, Kenneth ; Levitt, Roy C. / Asthma and bronchial hyperresponsiveness linked to the XY long arm pseudoautosomal region. In: Genomics. 1998 ; Vol. 52, No. 2. pp. 233-235.
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