TY - JOUR
T1 - Associations of sedentary behavior and abdominal muscle density
T2 - The multi-ethnic study of atherosclerosis
AU - Vella, Chantal A.
AU - Michos, Erin D.
AU - Sears, Dorothy D.
AU - Cushman, Mary
AU - Van Hollebeke, Rachel B.
AU - Wiest, Michelle M.
AU - Allison, Matthew A.
N1 - Funding Information:
The authors thank the other investigators, the staff, and the participants of the MESA study for their valuable contributions. A full list of participating MESA investigators and institutions can be found at http://www.mesa-nhlbi. org. This research was supported by contracts HHSN268201500003I, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168 and N01-HC-95169 and grant R01HL088451 from the National Heart, Lung, and Blood Institute and by grants UL1-TR-000040, UL1-TR-001079, and UL1-TR-001420 from NCATS. The article contents have not been previously presented elsewhere. No financial disclosures were reported by the authors of this paper.
Publisher Copyright:
© 2018 Human Kinetics, Inc.
PY - 2018/11
Y1 - 2018/11
N2 - Background: Sedentary behaviors (SB) may exacerbate loss of muscle mass and function, independent of physical activity levels. This study examined the associations of SB with abdominalmuscle area and density, amarker of muscle quality, in adults. Methods: A total of 1895 participants from the Multi-Ethnic Study of Atherosclerosis completed detailed health history, physical activity and SB questionnaires, computed tomography to quantify body composition, and measurements of inflammatory markers. Analyses included linear and nonlinear regression. Results: The mean age and body mass index were 64.6 years and 28 kg·m-2, respectively, and 50% were women. On average, participants engaged in 28 metabolic equivalent hours·week-1 of SB. With adjustment for age, sex, race/ethnicity, physical activity, cardiovascular disease risk factors, and inflammation, multivariable regression modeling revealed a nonlinear (quadratic) relationship between SB and locomotor, stability, and total abdominal muscle density (P < .01) but not muscle area. The SB inflection point at which locomotor, stability, and total abdominal muscle density began to decrease was 38.2, 39.6, and 39.2 metabolic equivalent hours·week-1 of SB, respectively. Conclusions: SB is associated with reduced muscle density when practiced as little as 5.5 metabolic equivalent hours·day-1. These findings may have important implications for SB guidelines for targeting skeletal muscle health in older adults.
AB - Background: Sedentary behaviors (SB) may exacerbate loss of muscle mass and function, independent of physical activity levels. This study examined the associations of SB with abdominalmuscle area and density, amarker of muscle quality, in adults. Methods: A total of 1895 participants from the Multi-Ethnic Study of Atherosclerosis completed detailed health history, physical activity and SB questionnaires, computed tomography to quantify body composition, and measurements of inflammatory markers. Analyses included linear and nonlinear regression. Results: The mean age and body mass index were 64.6 years and 28 kg·m-2, respectively, and 50% were women. On average, participants engaged in 28 metabolic equivalent hours·week-1 of SB. With adjustment for age, sex, race/ethnicity, physical activity, cardiovascular disease risk factors, and inflammation, multivariable regression modeling revealed a nonlinear (quadratic) relationship between SB and locomotor, stability, and total abdominal muscle density (P < .01) but not muscle area. The SB inflection point at which locomotor, stability, and total abdominal muscle density began to decrease was 38.2, 39.6, and 39.2 metabolic equivalent hours·week-1 of SB, respectively. Conclusions: SB is associated with reduced muscle density when practiced as little as 5.5 metabolic equivalent hours·day-1. These findings may have important implications for SB guidelines for targeting skeletal muscle health in older adults.
KW - Computed tomography
KW - Inflammation
KW - Muscle mass
KW - Obesity
KW - Physical activity
KW - Sitting
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U2 - 10.1123/jpah.2018-0028
DO - 10.1123/jpah.2018-0028
M3 - Article
C2 - 30301405
AN - SCOPUS:85055607324
SN - 1543-3080
VL - 15
SP - 827
EP - 833
JO - Journal of Physical Activity and Health
JF - Journal of Physical Activity and Health
IS - 11
ER -