Associations of cardiorespiratory fitness with cardiovascular disease risk factors in middle-aged Chinese women: A cross-sectional study

Wenfei Zhu, Steven P. Hooker, Yuliang Sun, Minhao Xie, Hao Su, Jianmin Cao

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: High levels of physical activity (PA) and cardiorespiratory fitness (CRF) are each associated with a favorable cardiovascular disease (CVD) risk profile. However, the relationship between CRF and obesity is still inconsistent across studies, and there has been no thorough exploration of the independent contribution of CRF to different CVD risk factors in Chinese women. This study investigated the relationship between CRF and CVD risk factors in 40-49 year old women in Beijing.Methods: The study included 231 urban-dwelling asymptomatic 40-49 year old women. Body mass index (BMI), body fat percentage (BF%), blood glucose, blood lipids, blood pressure, and pulse wave velocity (PWV) were measured at rest. Cycle ergometer exercise tests were conducted to assess CRF as indicated by maximal oxygen uptake (VO2max). Participants were categorized into three CRF levels (low, moderate and high).Results: High CRF level was associated with significantly less BF%, lower PWV, and higher weekly physical activity compared with low and moderate CRF (P < 0.05). Compared to high CRF, the odds ratios for having ≥3 main CVD risk factors (overweight, hypertension, and dyslipidemia) in low and moderate CRF were 2.09 (95% CI: 1.48-2.94) and 1.84 (95% CI: 1.29-2.62), respectively. The proportion of participants with clinical ST segment depression and prolonged QTC interval during cycle ergometer testing was significantly higher in women with low CRF.Conclusions: Overall, Chinese middle-aged women demonstrated a moderate level of CRF. CRF was independently associated with CVD risk factors, including overweight, hypertension, dyslipidemia, arterial stiffness, and abnormal ECG during exercise, with the least fit women exhibiting the highest number of CVD risk factors.

Original languageEnglish (US)
Article number62
JournalBMC Women's Health
Volume14
Issue number1
DOIs
StatePublished - May 1 2014

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Cardiovascular Diseases
Cross-Sectional Studies
Pulse Wave Analysis
Exercise
Dyslipidemias
Cardiorespiratory Fitness
Adipose Tissue
Hypertension
Vascular Stiffness
Physical Fitness
Exercise Test
Blood Glucose
Electrocardiography
Body Mass Index
Obesity
Odds Ratio
Oxygen
Blood Pressure
Lipids

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Associations of cardiorespiratory fitness with cardiovascular disease risk factors in middle-aged Chinese women : A cross-sectional study. / Zhu, Wenfei; Hooker, Steven P.; Sun, Yuliang; Xie, Minhao; Su, Hao; Cao, Jianmin.

In: BMC Women's Health, Vol. 14, No. 1, 62, 01.05.2014.

Research output: Contribution to journalArticle

Zhu, Wenfei ; Hooker, Steven P. ; Sun, Yuliang ; Xie, Minhao ; Su, Hao ; Cao, Jianmin. / Associations of cardiorespiratory fitness with cardiovascular disease risk factors in middle-aged Chinese women : A cross-sectional study. In: BMC Women's Health. 2014 ; Vol. 14, No. 1.
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AB - Background: High levels of physical activity (PA) and cardiorespiratory fitness (CRF) are each associated with a favorable cardiovascular disease (CVD) risk profile. However, the relationship between CRF and obesity is still inconsistent across studies, and there has been no thorough exploration of the independent contribution of CRF to different CVD risk factors in Chinese women. This study investigated the relationship between CRF and CVD risk factors in 40-49 year old women in Beijing.Methods: The study included 231 urban-dwelling asymptomatic 40-49 year old women. Body mass index (BMI), body fat percentage (BF%), blood glucose, blood lipids, blood pressure, and pulse wave velocity (PWV) were measured at rest. Cycle ergometer exercise tests were conducted to assess CRF as indicated by maximal oxygen uptake (VO2max). Participants were categorized into three CRF levels (low, moderate and high).Results: High CRF level was associated with significantly less BF%, lower PWV, and higher weekly physical activity compared with low and moderate CRF (P < 0.05). Compared to high CRF, the odds ratios for having ≥3 main CVD risk factors (overweight, hypertension, and dyslipidemia) in low and moderate CRF were 2.09 (95% CI: 1.48-2.94) and 1.84 (95% CI: 1.29-2.62), respectively. The proportion of participants with clinical ST segment depression and prolonged QTC interval during cycle ergometer testing was significantly higher in women with low CRF.Conclusions: Overall, Chinese middle-aged women demonstrated a moderate level of CRF. CRF was independently associated with CVD risk factors, including overweight, hypertension, dyslipidemia, arterial stiffness, and abnormal ECG during exercise, with the least fit women exhibiting the highest number of CVD risk factors.

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