@article{c1e50571edc741ff9615d86641ec7916,
title = "Associations of Biomarker-Calibrated Intake of Total Sugars with the Risk of Type 2 Diabetes and Cardiovascular Disease in the Women's Health Initiative Observational Study",
abstract = "The inconsistent findings from epidemiologic studies relating total sugars (TS) consumption to cardiovascular disease (CVD) or type 2 diabetes (T2D) risk may be partly due to measurement error in self-reported intake. Using regression calibration equations developed based on the predictive biomarker for TS and recovery biomarker for energy, we examined the association of TS with T2D and CVD risk, before and after dietary calibration, in 82,254 postmenopausal women participating in the Women's Health Initiative Observational Study. After up to 16 years of follow-up (1993-2010), 6,621 T2D and 5,802 CVD incident cases were identified. The hazard ratio for T2D per 20% increase in calibrated TS was 0.94 (95% confidence interval (CI): 0.77, 1.15) in multivariable energy substitution, and 1.00 (95% CI: 0.85, 1.18) in energy partition models. Multivariable hazard ratios for total CVD were 0.97 (95% CI: 0.87, 1.09) from energy substitution, and 0.91 (95% CI: 0.80, 1.04) from energy partition models. Uncalibrated TS generated a statistically significant inverse association with T2D and total CVD risk in multivariable energy substitution and energy partition models. The lack of conclusive findings from our calibrated analyses may be due to the low explanatory power of the calibration equations for TS, which could have led to incomplete deattenuation of the risk estimates.",
keywords = "Women's Health Initiative, calibration, cardiovascular disease, diabetes, diet, measurement error, total sugars",
author = "Natasha Tasevska and Mary Pettinger and Victor Kipnis and Douglas Midthune and Tinker, {Lesley F.} and Nancy Potischman and Neuhouser, {Marian L.} and Beasley, {Jeannette M.} and {Van Horn}, Linda and Howard, {Barbara V.} and Simin Liu and Manson, {Joann E.} and Shikany, {James M.} and Thomson, {Cynthia A.} and Prentice, {Ross L.}",
note = "Funding Information: Author affiliations: School of Nutrition and Health Promotion, College of Health Solutions, Arizona State University, Phoenix, Arizona (Natasha Tasevska); Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington (Mary Pettinger, Lesley F. Tinker, Marian L. Neuhouser, Ross L. Prentice); Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland (Victor Kipnis, Douglas Midthune); Population Studies Program, National Institutes of Health Office of Dietary Supplements, Bethesda, Maryland (Nancy Potischman); Division of General Internal Medicine and Clinical Innovation, New York University School of Medicine, New York, New York (Jeannette M. Beasley); Department of Preventive Medicine, Northwestern University, Chicago, Illinois (Linda Van Horn); Medstar Health Research Institute, Hyattsville, Maryland (Barbara V. Howard); Brown University, Providence, Rhode Island (Simin Liu); Brigham and Women{\textquoteright}s Hospital, Harvard Medical School, Boston, Massachusetts (JoAnn E. Manson); University of Alabama at Birmingham, Birmingham, Alabama (James M. Shikany); and Department of Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona (Cynthia A. Thomson). This work was supported by the National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, US Department of Health and Human Services (contracts HHSN268201100046C, HHSN268201100001C, HHSN268201100002C, HHSN268201100003C, HHSN268201100004C, and HHSN271201100004C) and the National Cancer Institute (grant R01 CA119171). We acknowledge the following investigators in the Women{\textquoteright}s Health Initiative (WHI) Program: Program Office at the National Heart, Lung, and Blood Institute (NHLBI), Bethesda, Maryland: Jacques Rossouw, Shari Ludlam, Dale Burwen, Joan McGowan, Leslie Ford, and Nancy Geller; Clinical Coordinating Center at Fred Hutchinson Cancer Research Center, Seattle, Washington: Garnet Anderson, Ross Prentice, Andrea LaCroix, and Charles Kooperberg. We thank the following investigators and academic centers: Brigham and Women{\textquoteright}s Hospital, Harvard Medical School, Boston, Massachusetts: JoAnn E. Manson; MedStar Health Research Institute and Howard University, Washington, DC: Barbara V. Howard; Stanford Prevention Research Center, Stanford, California: Marcia L. Stefanick; The Ohio State University, Columbus, Ohio: Rebecca Jackson; the Tucson and Phoenix, Arizona, campuses of University of Arizona: Cynthia A. Thomson; University at Buffalo, Buffalo, New York: Jean Wactawski-Wende; the Gainesville and Jacksonville, Florida, campuses of University of Florida: Marian Limacher; the Iowa City and Davenport, Iowa, campuses of University of Iowa: Jennifer Robinson; University of Pittsburgh, Pittsburgh, Pennsylvania: Lewis Kuller; Wake Forest University School of Medicine, Winston-Salem, North Carolina: Sally Shumaker; University of Nevada, Reno, Nevada: Robert Brunner; University of Minnesota, Minneapolis, Minnesota: Karen L. Margolis; and with the WHI Memory Study at Wake Forest University Publisher Copyright: {\textcopyright} Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health 2018.",
year = "2018",
month = oct,
day = "1",
doi = "10.1093/aje/kwy115",
language = "English (US)",
volume = "187",
pages = "2126--2135",
journal = "American Journal of Epidemiology",
issn = "0002-9262",
publisher = "Oxford University Press",
number = "10",
}