Abstract
OBJECTIVE: This study evaluated whether measures of waking or diurnal cortisol secretion, or self-reported psychological disturbances differed among police officers with a Period3 (PER3) clock gene length polymorphism. METHODS: The cortisol awakening response was characterized via the area under the salivary cortisol curve with respect to the increase (AUC1) or total waking cortisol (AUCG). Diurnal cortisol measures included the slope of diurnal cortisol and the diurnal AUCG. Psychological disturbances were characterized using the Center for Epidemiologic Studies Depression Scale, Impact of Events Scale, and Life Events Scale. RESULTS: Officers with a 4/5 or 5/5 genotype had higher awakening AUCG and greater diurnal Cortisol AUCG levels compared to officers with the 4/4 genotype. Among those working more afternoon or night shifts, waking AUCI and AUC G were greater among officers with a 4/5 or 5/5 genotype compared to the 4/4 referents. CONCLUSION: Cortisol secretion was modified among police officers with different PER3 VNTR clock gene variants.
Original language | English (US) |
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Pages (from-to) | 27-37 |
Number of pages | 11 |
Journal | Neuroendocrinology Letters |
Volume | 34 |
Issue number | 1 |
State | Published - 2013 |
Externally published | Yes |
Keywords
- Circadian
- Cortisol
- PER3 VNTR
- Police
- Shiftwork
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology
- Neurology
- Endocrine and Autonomic Systems
- Clinical Neurology
- Psychiatry and Mental health