TY - JOUR
T1 - Association of sleep duration with kidney function and albuminuria
T2 - NHANES 2009-2012
AU - Petrov, Megan
AU - Buman, Matthew
AU - Unruh, Mark L.
AU - Baldwin, Carol M.
AU - Jeong, Mihyun
AU - Reynaga-Ornelas, Luxana
AU - Youngstedt, Shawn
N1 - Funding Information:
Dr Petrov would like to acknowledge that research assistance for data analysis and manuscript development was supported by training funds from the National Institute on Minority Health and Health Disparities of the National Institutes of Health (NIMHD/NIH), award P20 MD002316 (F Marsiglia, PI). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIMHD or the NIH. Dr Youngstedt would like to acknowledge the support of the National Heart, Lung, and Blood Institute, award RO1- HL095799. No other support to report. No financial relationships to disclose.
Funding Information:
Support and Financial Disclosure: Dr Petrov would like to acknowledge that research assistance for data analysis and manuscript development was supported by training funds from the National Institute on Minority Health and Health Disparities of the National Institutes of Health (NIMHD/NIH), award P20 MD002316 (F Marsiglia, PI). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIMHD or the NIH. Dr Youngstedt would like to acknowledge the support of the National Heart, Lung, and Blood Institute, award RO1-HL095799. No other support to report. No financial relationships to disclose.
Publisher Copyright:
© 2016 National Sleep Foundation.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Objective: The purpose of this study was to examine the association between self-reported sleep duration and markers of kidney function. Design: A cross-sectional survey from the 2009-2012 National Health and Nutrition Examination Survey. Setting and Participants: The participants were 8690 adults (≥. 20 years) without a previous sleep disorder diagnosis, end-stage kidney failure, or other kidney or liver problems. Subsamples with pre-diabetes and pre-hypertension were examined. Measurements: Participants reported habitual sleep duration, coded as ≤. 5, 6, 7, 8, and ≥. 9 hours per night. Biomarkers of kidney function were determined, including glomerular filtration rate (eGFR) estimated from the Chronic Kidney Disease Epidemiology Collaboration equation, urine albumin-to-creatinine ratio (ACR), microalbuminuria status, and glomerular hyperfiltration status. Weighted and adjusted general linear models assessed associations between sleep duration with eGFR and ACR. Logistic regression analyses evaluated the associations of microalbuminuria and glomerular hyperfiltration status with sleep duration. Results: Greater eGFR was related to short sleep duration in the total sample and among participants with pre-diabetes. Greater ACR was associated with short and long sleep duration. Short sleep duration (≤. 5 hours) was associated with an increased odds for glomerular hyperfiltration (OR, 1.41; 95% CI, 0.97-2.06) and microalbuminuria (OR, 1.31; 95% CI, 0.96-1.79). Conclusions: In a US representative sample of adults, self-reported short and long sleep duration were related to higher ACR. Short sleep duration was associated with higher eGFR and microalbuminuria. Research is needed to understand whether these associations indicate increased risk for kidney damage and cardiovascular risk.
AB - Objective: The purpose of this study was to examine the association between self-reported sleep duration and markers of kidney function. Design: A cross-sectional survey from the 2009-2012 National Health and Nutrition Examination Survey. Setting and Participants: The participants were 8690 adults (≥. 20 years) without a previous sleep disorder diagnosis, end-stage kidney failure, or other kidney or liver problems. Subsamples with pre-diabetes and pre-hypertension were examined. Measurements: Participants reported habitual sleep duration, coded as ≤. 5, 6, 7, 8, and ≥. 9 hours per night. Biomarkers of kidney function were determined, including glomerular filtration rate (eGFR) estimated from the Chronic Kidney Disease Epidemiology Collaboration equation, urine albumin-to-creatinine ratio (ACR), microalbuminuria status, and glomerular hyperfiltration status. Weighted and adjusted general linear models assessed associations between sleep duration with eGFR and ACR. Logistic regression analyses evaluated the associations of microalbuminuria and glomerular hyperfiltration status with sleep duration. Results: Greater eGFR was related to short sleep duration in the total sample and among participants with pre-diabetes. Greater ACR was associated with short and long sleep duration. Short sleep duration (≤. 5 hours) was associated with an increased odds for glomerular hyperfiltration (OR, 1.41; 95% CI, 0.97-2.06) and microalbuminuria (OR, 1.31; 95% CI, 0.96-1.79). Conclusions: In a US representative sample of adults, self-reported short and long sleep duration were related to higher ACR. Short sleep duration was associated with higher eGFR and microalbuminuria. Research is needed to understand whether these associations indicate increased risk for kidney damage and cardiovascular risk.
KW - Albuminuria
KW - Chronic kidney disease
KW - Glomerular filtration rate
KW - National survey
KW - Renal function
KW - Sleep duration
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U2 - 10.1016/j.sleh.2015.12.003
DO - 10.1016/j.sleh.2015.12.003
M3 - Article
AN - SCOPUS:84958856363
SN - 2352-7218
VL - 2
SP - 75
EP - 81
JO - Sleep Health
JF - Sleep Health
IS - 1
ER -