Association of selenium and copper with lipids in umbilical cord blood

E. M. Wells, A. Navas-Acien, B. J. Apelberg, J. B. Herbstman, J. M. Jarrett, Y. H. Lin, C. P. Verdon, C. Ward, K. L. Caldwell, J. R. Hibbeln, Rolf Halden, F. R. Witter, L. R. Goldman

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Altered levels of selenium and copper have been linked with altered cardiovascular disease risk factors including changes in blood triglyceride and cholesterol levels. However, it is unclear whether this can be observed prenatally. This cross-sectional study includes 274 singleton births from 2004 to 2005 in Baltimore, Maryland. We measured umbilical cord serum selenium and copper using inductively coupled plasma mass spectrometry. We evaluated exposure levels vis-à-vis umbilical cord serum triglyceride and total cholesterol concentrations in multivariable regression models adjusted for gestational age, birth weight, maternal age, race, parity, smoking, prepregnancy body mass index, n-3 fatty acids and methyl mercury. The percent difference in triglycerides comparing those in the highest v. lowest quartile of selenium was 22.3% (95% confidence interval (CI): 7.1, 39.7). For copper this was 43.8% (95% CI: 25.9, 64.3). In multivariable models including both copper and selenium as covariates, copper, but not selenium, maintained a statistically significant association with increased triglycerides (percent difference: 40.7%, 95% CI: 22.1, 62.1). There was limited evidence of a relationship of increasing selenium with increasing total cholesterol. Our findings provide evidence that higher serum copper levels are associated with higher serum triglycerides in newborns, but should be confirmed in larger studies.

Original languageEnglish (US)
Pages (from-to)281-287
Number of pages7
JournalJournal of Developmental Origins of Health and Disease
Volume5
Issue number4
DOIs
StatePublished - 2014

Fingerprint

Selenium
Fetal Blood
Copper
Triglycerides
Lipids
Umbilical Cord
Cholesterol
Confidence Intervals
Serum
Baltimore
Maternal Age
Omega-3 Fatty Acids
Parity
Mercury
Birth Weight
Gestational Age
Mass Spectrometry
Body Mass Index
Cardiovascular Diseases
Cross-Sectional Studies

Keywords

  • copper
  • infant
  • newborn
  • selenium
  • total cholesterol
  • triglyceride

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Medicine(all)

Cite this

Wells, E. M., Navas-Acien, A., Apelberg, B. J., Herbstman, J. B., Jarrett, J. M., Lin, Y. H., ... Goldman, L. R. (2014). Association of selenium and copper with lipids in umbilical cord blood. Journal of Developmental Origins of Health and Disease, 5(4), 281-287. https://doi.org/10.1017/S2040174414000233

Association of selenium and copper with lipids in umbilical cord blood. / Wells, E. M.; Navas-Acien, A.; Apelberg, B. J.; Herbstman, J. B.; Jarrett, J. M.; Lin, Y. H.; Verdon, C. P.; Ward, C.; Caldwell, K. L.; Hibbeln, J. R.; Halden, Rolf; Witter, F. R.; Goldman, L. R.

In: Journal of Developmental Origins of Health and Disease, Vol. 5, No. 4, 2014, p. 281-287.

Research output: Contribution to journalArticle

Wells, EM, Navas-Acien, A, Apelberg, BJ, Herbstman, JB, Jarrett, JM, Lin, YH, Verdon, CP, Ward, C, Caldwell, KL, Hibbeln, JR, Halden, R, Witter, FR & Goldman, LR 2014, 'Association of selenium and copper with lipids in umbilical cord blood', Journal of Developmental Origins of Health and Disease, vol. 5, no. 4, pp. 281-287. https://doi.org/10.1017/S2040174414000233
Wells, E. M. ; Navas-Acien, A. ; Apelberg, B. J. ; Herbstman, J. B. ; Jarrett, J. M. ; Lin, Y. H. ; Verdon, C. P. ; Ward, C. ; Caldwell, K. L. ; Hibbeln, J. R. ; Halden, Rolf ; Witter, F. R. ; Goldman, L. R. / Association of selenium and copper with lipids in umbilical cord blood. In: Journal of Developmental Origins of Health and Disease. 2014 ; Vol. 5, No. 4. pp. 281-287.
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