Association of neuropeptide Y receptor Y5 polymorphisms with dyslipidemia in Mexican Americans

Dawn K. Coletta; Jennifer Schneider; Michael P. Stern; John Blangero; Ralph A. DeFronzo; Ravindranath Duggirala; Christopher P. Jenkinson

doi:10.1038/oby.2007.610

Association of neuropeptide Y receptor Y5 polymorphisms with dyslipidemia in Mexican Americans

Dawn K. Coletta, Jennifer Schneider, Michael P. Stern, John Blangero, Ralph A. DeFronzo, Ravindranath Duggirala, Christopher P. Jenkinson

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

We examined the genetic association of neuropeptide Y receptor Y5 (NPY5R) single nucleotide polymorphisms (SNPs) with measures of the insulin resistance (metabolic) syndrome. We genotyped 10 NPY5R SNPs in 439 Mexican American individuals (age = 43.3 ± 17.3 years and BMI = 30.0 ± 6.7 kg/m²) distributed across 27 pedigrees from the San Antonio Family Diabetes Study and performed association analyses using the measured genotype approach as implemented in Sequential Oligogenic Linkage Analysis Routines (SOLAR). Minor alleles for five (rs11100493, rs12501691, P1, rs11100494, rs12512687) of the NPY5R SNPs were found to be significantly (p < 0.05) associated with fasting plasma triglyceride concentrations and decreased high-density lipoprotein concentrations. In addition, the minor allele for SNP P2 was significantly associated (p = 0.031) with a decreased homeostasis model assessment of β-cell function (HOMA-%β). Linkage disequilibrium between SNP pairs indicated one haplotype block of five SNPs (rs11100493, rs12501691, P1, rs11100494, rs12512687) that were highly correlated (r ² > 0.98). These preliminary results provide evidence for association of SNPs in the NPY5R gene with dyslipidemia (elevated triglyceride concentrations and reduced high-density lipopro tein levels) in our Mexican American population.

Original language	English (US)
Pages (from-to)	809-815
Number of pages	7
Journal	Obesity
Volume	15
Issue number	4
DOIs	https://doi.org/10.1038/oby.2007.610
State	Published - Apr 2007
Externally published	Yes

Keywords

Dyslipidemia
Genetic susceptibility
Insulin resistance
Metabolic syndrome
Neuropeptide Y

ASJC Scopus subject areas

Medicine (miscellaneous)
Endocrinology, Diabetes and Metabolism
Endocrinology
Nutrition and Dietetics

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10.1038/oby.2007.610

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@article{0b2be3b2aeef422dad676ab8804419cb,

title = "Association of neuropeptide Y receptor Y5 polymorphisms with dyslipidemia in Mexican Americans",

abstract = "We examined the genetic association of neuropeptide Y receptor Y5 (NPY5R) single nucleotide polymorphisms (SNPs) with measures of the insulin resistance (metabolic) syndrome. We genotyped 10 NPY5R SNPs in 439 Mexican American individuals (age = 43.3 ± 17.3 years and BMI = 30.0 ± 6.7 kg/m2) distributed across 27 pedigrees from the San Antonio Family Diabetes Study and performed association analyses using the measured genotype approach as implemented in Sequential Oligogenic Linkage Analysis Routines (SOLAR). Minor alleles for five (rs11100493, rs12501691, P1, rs11100494, rs12512687) of the NPY5R SNPs were found to be significantly (p < 0.05) associated with fasting plasma triglyceride concentrations and decreased high-density lipoprotein concentrations. In addition, the minor allele for SNP P2 was significantly associated (p = 0.031) with a decreased homeostasis model assessment of β-cell function (HOMA-%β). Linkage disequilibrium between SNP pairs indicated one haplotype block of five SNPs (rs11100493, rs12501691, P1, rs11100494, rs12512687) that were highly correlated (r 2 > 0.98). These preliminary results provide evidence for association of SNPs in the NPY5R gene with dyslipidemia (elevated triglyceride concentrations and reduced high-density lipopro tein levels) in our Mexican American population.",

keywords = "Dyslipidemia, Genetic susceptibility, Insulin resistance, Metabolic syndrome, Neuropeptide Y",

author = "Coletta, {Dawn K.} and Jennifer Schneider and Stern, {Michael P.} and John Blangero and DeFronzo, {Ralph A.} and Ravindranath Duggirala and Jenkinson, {Christopher P.}",

year = "2007",

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language = "English (US)",

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T1 - Association of neuropeptide Y receptor Y5 polymorphisms with dyslipidemia in Mexican Americans

AU - Coletta, Dawn K.

AU - Schneider, Jennifer

AU - Stern, Michael P.

AU - Blangero, John

AU - DeFronzo, Ralph A.

AU - Duggirala, Ravindranath

AU - Jenkinson, Christopher P.

PY - 2007/4

Y1 - 2007/4

N2 - We examined the genetic association of neuropeptide Y receptor Y5 (NPY5R) single nucleotide polymorphisms (SNPs) with measures of the insulin resistance (metabolic) syndrome. We genotyped 10 NPY5R SNPs in 439 Mexican American individuals (age = 43.3 ± 17.3 years and BMI = 30.0 ± 6.7 kg/m2) distributed across 27 pedigrees from the San Antonio Family Diabetes Study and performed association analyses using the measured genotype approach as implemented in Sequential Oligogenic Linkage Analysis Routines (SOLAR). Minor alleles for five (rs11100493, rs12501691, P1, rs11100494, rs12512687) of the NPY5R SNPs were found to be significantly (p < 0.05) associated with fasting plasma triglyceride concentrations and decreased high-density lipoprotein concentrations. In addition, the minor allele for SNP P2 was significantly associated (p = 0.031) with a decreased homeostasis model assessment of β-cell function (HOMA-%β). Linkage disequilibrium between SNP pairs indicated one haplotype block of five SNPs (rs11100493, rs12501691, P1, rs11100494, rs12512687) that were highly correlated (r 2 > 0.98). These preliminary results provide evidence for association of SNPs in the NPY5R gene with dyslipidemia (elevated triglyceride concentrations and reduced high-density lipopro tein levels) in our Mexican American population.

AB - We examined the genetic association of neuropeptide Y receptor Y5 (NPY5R) single nucleotide polymorphisms (SNPs) with measures of the insulin resistance (metabolic) syndrome. We genotyped 10 NPY5R SNPs in 439 Mexican American individuals (age = 43.3 ± 17.3 years and BMI = 30.0 ± 6.7 kg/m2) distributed across 27 pedigrees from the San Antonio Family Diabetes Study and performed association analyses using the measured genotype approach as implemented in Sequential Oligogenic Linkage Analysis Routines (SOLAR). Minor alleles for five (rs11100493, rs12501691, P1, rs11100494, rs12512687) of the NPY5R SNPs were found to be significantly (p < 0.05) associated with fasting plasma triglyceride concentrations and decreased high-density lipoprotein concentrations. In addition, the minor allele for SNP P2 was significantly associated (p = 0.031) with a decreased homeostasis model assessment of β-cell function (HOMA-%β). Linkage disequilibrium between SNP pairs indicated one haplotype block of five SNPs (rs11100493, rs12501691, P1, rs11100494, rs12512687) that were highly correlated (r 2 > 0.98). These preliminary results provide evidence for association of SNPs in the NPY5R gene with dyslipidemia (elevated triglyceride concentrations and reduced high-density lipopro tein levels) in our Mexican American population.

KW - Dyslipidemia

KW - Genetic susceptibility

KW - Insulin resistance

KW - Metabolic syndrome

KW - Neuropeptide Y

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Association of neuropeptide Y receptor Y5 polymorphisms with dyslipidemia in Mexican Americans

Abstract

Keywords

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