Association of neuropeptide Y receptor Y5 polymorphisms with dyslipidemia in Mexican Americans

Dawn K. Coletta, Jennifer Schneider, Michael P. Stern, John Blangero, Ralph A. DeFronzo, Ravindranath Duggirala, Christopher P. Jenkinson

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

We examined the genetic association of neuropeptide Y receptor Y5 (NPY5R) single nucleotide polymorphisms (SNPs) with measures of the insulin resistance (metabolic) syndrome. We genotyped 10 NPY5R SNPs in 439 Mexican American individuals (age = 43.3 ± 17.3 years and BMI = 30.0 ± 6.7 kg/m2) distributed across 27 pedigrees from the San Antonio Family Diabetes Study and performed association analyses using the measured genotype approach as implemented in Sequential Oligogenic Linkage Analysis Routines (SOLAR). Minor alleles for five (rs11100493, rs12501691, P1, rs11100494, rs12512687) of the NPY5R SNPs were found to be significantly (p < 0.05) associated with fasting plasma triglyceride concentrations and decreased high-density lipoprotein concentrations. In addition, the minor allele for SNP P2 was significantly associated (p = 0.031) with a decreased homeostasis model assessment of β-cell function (HOMA-%β). Linkage disequilibrium between SNP pairs indicated one haplotype block of five SNPs (rs11100493, rs12501691, P1, rs11100494, rs12512687) that were highly correlated (r 2 > 0.98). These preliminary results provide evidence for association of SNPs in the NPY5R gene with dyslipidemia (elevated triglyceride concentrations and reduced high-density lipopro tein levels) in our Mexican American population.

Original languageEnglish (US)
Pages (from-to)809-815
Number of pages7
JournalObesity
Volume15
Issue number4
DOIs
StatePublished - Apr 2007

Keywords

  • Dyslipidemia
  • Genetic susceptibility
  • Insulin resistance
  • Metabolic syndrome
  • Neuropeptide Y

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

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