Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals

Jason J. Corneveaux; Amanda J. Myers; April N. Allen; Jeremy J. Pruzin; Manuel Ramirez; Anzhelika Engel; Michael A. Nalls; Kewei Chen; Wendy Lee; Kendria Chewning; Stephen E. Villa; Hunsar B. Meechoovet; Jill D. Gerber; Danielle Frost; Hollie L. Benson; Sean O'Reilly; Lori B. Chibnik; Joshua M. Shulman; Andrew B. Singleton; David W. Craig; Kendall R. Van Keuren-Jensen; Travis Dunckley; David A. Bennett; Philip L. de Jager; Christopher Heward; John Hardy; Eric M. Reiman; Matthew J. Huentelman

doi:10.1093/hmg/ddq221

Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals

Jason J. Corneveaux, Amanda J. Myers, April N. Allen, Jeremy J. Pruzin, Manuel Ramirez, Anzhelika Engel, Michael A. Nalls, Kewei Chen, Wendy Lee, Kendria Chewning, Stephen E. Villa, Hunsar B. Meechoovet, Jill D. Gerber, Danielle Frost, Hollie L. Benson, Sean O'Reilly, Lori B. Chibnik, Joshua M. Shulman, Andrew B. Singleton, David W. CraigKendall R. Van Keuren-Jensen, Travis Dunckley, David A. Bennett, Philip L. de Jager, Christopher Heward, John Hardy, Eric M. Reiman, Matthew J. Huentelman

BI: ASU-Banner Neurodegenerative Disease Research Center (NDRC)

Research output: Contribution to journal › Article

186 Scopus citations

Abstract

In this study, we assess 34 of the most replicated genetic associations for Alzheimer's disease (AD) using data generated on Affymetrix SNP 6.0 arrays and imputed at over 5.7 million markers from a unique cohort of over 1600 neuropathologically defined AD cases and controls (1019 cases and 591 controls). Testing the top genes from the AlzGene meta-analysis, we confirm the well-known association with APOE single nucleotide polymorphisms (SNPs), the CLU, PICALM and CR1 SNPs recently implicated in unusually large data sets, and previously implicated CST3 and ACE SNPs. In the cases of CLU, PICALM and CR1,aswell as in APOE, the odds ratios we find are slightly larger than those previously reported in clinical samples, consistent with what we believe to be more accurate classification of disease in the clinically characterized and neuropathologically confirmed AD cases and controls.

Original language	English (US)
Article number	ddq221
Pages (from-to)	3295-3301
Number of pages	7
Journal	Human Molecular Genetics
Volume	19
Issue number	16
DOIs	https://doi.org/10.1093/hmg/ddq221
State	Published - Jun 9 2010

ASJC Scopus subject areas

Molecular Biology
Genetics
Genetics(clinical)

Access to Document

10.1093/hmg/ddq221

Fingerprint Dive into the research topics of 'Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals'. Together they form a unique fingerprint.

Cite this

Corneveaux, J. J., Myers, A. J., Allen, A. N., Pruzin, J. J., Ramirez, M., Engel, A., Nalls, M. A., Chen, K., Lee, W., Chewning, K., Villa, S. E., Meechoovet, H. B., Gerber, J. D., Frost, D., Benson, H. L., O'Reilly, S., Chibnik, L. B., Shulman, J. M., Singleton, A. B., ... Huentelman, M. J. (2010). Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. Human Molecular Genetics, 19(16), 3295-3301. [ddq221]. https://doi.org/10.1093/hmg/ddq221

Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. / Corneveaux, Jason J.; Myers, Amanda J.; Allen, April N.; Pruzin, Jeremy J.; Ramirez, Manuel; Engel, Anzhelika; Nalls, Michael A.; Chen, Kewei; Lee, Wendy; Chewning, Kendria; Villa, Stephen E.; Meechoovet, Hunsar B.; Gerber, Jill D.; Frost, Danielle; Benson, Hollie L.; O'Reilly, Sean; Chibnik, Lori B.; Shulman, Joshua M.; Singleton, Andrew B.; Craig, David W.; Van Keuren-Jensen, Kendall R.; Dunckley, Travis; Bennett, David A.; de Jager, Philip L.; Heward, Christopher; Hardy, John; Reiman, Eric M.; Huentelman, Matthew J.

In: Human Molecular Genetics, Vol. 19, No. 16, ddq221, 09.06.2010, p. 3295-3301.

Research output: Contribution to journal › Article

Corneveaux, JJ, Myers, AJ, Allen, AN, Pruzin, JJ, Ramirez, M, Engel, A, Nalls, MA, Chen, K, Lee, W, Chewning, K, Villa, SE, Meechoovet, HB, Gerber, JD, Frost, D, Benson, HL, O'Reilly, S, Chibnik, LB, Shulman, JM, Singleton, AB, Craig, DW, Van Keuren-Jensen, KR, Dunckley, T, Bennett, DA, de Jager, PL, Heward, C, Hardy, J, Reiman, EM & Huentelman, MJ 2010, 'Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals', Human Molecular Genetics, vol. 19, no. 16, ddq221, pp. 3295-3301. https://doi.org/10.1093/hmg/ddq221

Corneveaux, Jason J. ; Myers, Amanda J. ; Allen, April N. ; Pruzin, Jeremy J. ; Ramirez, Manuel ; Engel, Anzhelika ; Nalls, Michael A. ; Chen, Kewei ; Lee, Wendy ; Chewning, Kendria ; Villa, Stephen E. ; Meechoovet, Hunsar B. ; Gerber, Jill D. ; Frost, Danielle ; Benson, Hollie L. ; O'Reilly, Sean ; Chibnik, Lori B. ; Shulman, Joshua M. ; Singleton, Andrew B. ; Craig, David W. ; Van Keuren-Jensen, Kendall R. ; Dunckley, Travis ; Bennett, David A. ; de Jager, Philip L. ; Heward, Christopher ; Hardy, John ; Reiman, Eric M. ; Huentelman, Matthew J. / Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. In: Human Molecular Genetics. 2010 ; Vol. 19, No. 16. pp. 3295-3301.

@article{2a3b3a7d3d094aca9c777930e67c6f0a,

title = "Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals",

abstract = "In this study, we assess 34 of the most replicated genetic associations for Alzheimer's disease (AD) using data generated on Affymetrix SNP 6.0 arrays and imputed at over 5.7 million markers from a unique cohort of over 1600 neuropathologically defined AD cases and controls (1019 cases and 591 controls). Testing the top genes from the AlzGene meta-analysis, we confirm the well-known association with APOE single nucleotide polymorphisms (SNPs), the CLU, PICALM and CR1 SNPs recently implicated in unusually large data sets, and previously implicated CST3 and ACE SNPs. In the cases of CLU, PICALM and CR1,aswell as in APOE, the odds ratios we find are slightly larger than those previously reported in clinical samples, consistent with what we believe to be more accurate classification of disease in the clinically characterized and neuropathologically confirmed AD cases and controls.",

author = "Corneveaux, {Jason J.} and Myers, {Amanda J.} and Allen, {April N.} and Pruzin, {Jeremy J.} and Manuel Ramirez and Anzhelika Engel and Nalls, {Michael A.} and Kewei Chen and Wendy Lee and Kendria Chewning and Villa, {Stephen E.} and Meechoovet, {Hunsar B.} and Gerber, {Jill D.} and Danielle Frost and Benson, {Hollie L.} and Sean O'Reilly and Chibnik, {Lori B.} and Shulman, {Joshua M.} and Singleton, {Andrew B.} and Craig, {David W.} and {Van Keuren-Jensen}, {Kendall R.} and Travis Dunckley and Bennett, {David A.} and {de Jager}, {Philip L.} and Christopher Heward and John Hardy and Reiman, {Eric M.} and Huentelman, {Matthew J.}",

year = "2010",

month = jun,

day = "9",

doi = "10.1093/hmg/ddq221",

language = "English (US)",

volume = "19",

pages = "3295--3301",

journal = "Human Molecular Genetics",

issn = "0964-6906",

publisher = "Oxford University Press",

number = "16",

}

TY - JOUR

T1 - Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals

AU - Corneveaux, Jason J.

AU - Myers, Amanda J.

AU - Allen, April N.

AU - Pruzin, Jeremy J.

AU - Ramirez, Manuel

AU - Engel, Anzhelika

AU - Nalls, Michael A.

AU - Chen, Kewei

AU - Lee, Wendy

AU - Chewning, Kendria

AU - Villa, Stephen E.

AU - Meechoovet, Hunsar B.

AU - Gerber, Jill D.

AU - Frost, Danielle

AU - Benson, Hollie L.

AU - O'Reilly, Sean

AU - Chibnik, Lori B.

AU - Shulman, Joshua M.

AU - Singleton, Andrew B.

AU - Craig, David W.

AU - Van Keuren-Jensen, Kendall R.

AU - Dunckley, Travis

AU - Bennett, David A.

AU - de Jager, Philip L.

AU - Heward, Christopher

AU - Hardy, John

AU - Reiman, Eric M.

AU - Huentelman, Matthew J.

PY - 2010/6/9

Y1 - 2010/6/9

N2 - In this study, we assess 34 of the most replicated genetic associations for Alzheimer's disease (AD) using data generated on Affymetrix SNP 6.0 arrays and imputed at over 5.7 million markers from a unique cohort of over 1600 neuropathologically defined AD cases and controls (1019 cases and 591 controls). Testing the top genes from the AlzGene meta-analysis, we confirm the well-known association with APOE single nucleotide polymorphisms (SNPs), the CLU, PICALM and CR1 SNPs recently implicated in unusually large data sets, and previously implicated CST3 and ACE SNPs. In the cases of CLU, PICALM and CR1,aswell as in APOE, the odds ratios we find are slightly larger than those previously reported in clinical samples, consistent with what we believe to be more accurate classification of disease in the clinically characterized and neuropathologically confirmed AD cases and controls.

AB - In this study, we assess 34 of the most replicated genetic associations for Alzheimer's disease (AD) using data generated on Affymetrix SNP 6.0 arrays and imputed at over 5.7 million markers from a unique cohort of over 1600 neuropathologically defined AD cases and controls (1019 cases and 591 controls). Testing the top genes from the AlzGene meta-analysis, we confirm the well-known association with APOE single nucleotide polymorphisms (SNPs), the CLU, PICALM and CR1 SNPs recently implicated in unusually large data sets, and previously implicated CST3 and ACE SNPs. In the cases of CLU, PICALM and CR1,aswell as in APOE, the odds ratios we find are slightly larger than those previously reported in clinical samples, consistent with what we believe to be more accurate classification of disease in the clinically characterized and neuropathologically confirmed AD cases and controls.

UR - http://www.scopus.com/inward/record.url?scp=77955036445&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955036445&partnerID=8YFLogxK

U2 - 10.1093/hmg/ddq221

DO - 10.1093/hmg/ddq221

M3 - Article

C2 - 20534741

AN - SCOPUS:77955036445

VL - 19

SP - 3295

EP - 3301

JO - Human Molecular Genetics

JF - Human Molecular Genetics

SN - 0964-6906

IS - 16

M1 - ddq221

ER -