@article{d83fc4abf70747b9b4da1f3cde1db269,
title = "Association of AEBP1 and NRN1 RNA expression with Alzheimer's disease and neurofibrillary tangle density in middle temporal gyrus",
abstract = "We explored RNA expression changes in the middle temporal gyrus (MTG) of Alzheimer's Disease patients (AD) by RNA sequencing the whole transcriptome of 8 AD and 8 Non-Demented (ND) controls. We used three additional expression datasets from related brain regions to validate the findings. The results highlighted the upregulation of AEBP1 and downregulation of NRN1 in AD, as well as their association with Braak staging and neurofibrillary tangles density. Furthermore, more than 400 protein-coding RNAs enriched for “Clathrin-mediated endocytosis” were validated in independent datasets from the same brain region. Finally, using in silico prediction analysis we found a signature of 52 non-protein coding RNAs that perturb key pathways involved in GABAergic transmission and peptide chain elongation. The association of AEBP1 in our data confirmed other published work examining gene expression in the hippocampus of AD patients. NRN1 is involved in neurite outgrowth, and in previous studies it has been shown to reverse synaptic defects and cognitive function impairment in Tg2576 mice. Finally, our results on non-protein coding RNAs suggest a role of these transcripts in altering synaptic and amyloid-β associated pathways.",
keywords = "AEBP1, Alzheimer's disease, Braak staging, Neurofibrillary tangles, Non-protein coding RNAs, RNA sequencing",
author = "Piras, {Ignazio S.} and Jonida Krate and Elaine Delvaux and Jennifer Nolz and {De Both}, {Matthew D.} and Mastroeni, {Diego F.} and Serrano, {Geidy E.} and Sue, {Lucia I.} and Beach, {Thomas G.} and Coleman, {Paul D.} and Huentelman, {Matthew J.}",
note = "Funding Information: 1. The Mayo Clinic Brain Bank. Data collection was supported through funding by NIA grants P50 AG016574 , R01 AG032990 , U01 AG046139 , R01 AG018023 , U01 AG006576 , U01 AG006786 , R01 AG025711 , R01 AG017216 , R01 AG003949 , NINDS grant R01 NS080820 , CurePSP Foundation , and support from Mayo Foundation . Funding Information: We are grateful to the Banner Sun Health Research Institute Brain and Body Donation Program of Sun City, Arizona for the provision of human biological materials (or specific description, e.g. brain tissue, cerebrospinal fluid). The Brain and Body Donation Program has been supported by the National Institute of Neurological Disorders and Stroke ( U24 NS072026 National Brain and Tissue Resource for Parkinson{\textquoteright}s Disease and Related Disorders), the National Institute on Aging ( P30 AG19610 Arizona Alzheimer{\textquoteright}s Disease Core Center), the Arizona Department of Health Services (contract 211002 , Arizona Alzheimer{\textquoteright}s Research Center), the Arizona Biomedical Research Commission (contracts 4001 , 0011 , 05-901 and 1001 to the Arizona Parkinson's Disease Consortium) and the Michael J. Fox Foundation for Parkinson{\textquoteright}s Research. Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",
year = "2019",
month = sep,
day = "15",
doi = "10.1016/j.brainres.2019.06.004",
language = "English (US)",
volume = "1719",
pages = "217--224",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
}